Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 64997..65646 Replicon chromosome
Accession NZ_CP114801
Organism Citrobacter sp. 21OH12SH02A-Citro

Toxin (Protein)


Gene name higB Uniprot ID A0A7L6TVT2
Locus tag O6D90_RS00325 Protein ID WP_016157800.1
Coordinates 64997..65338 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A7L6TWH1
Locus tag O6D90_RS00330 Protein ID WP_016157799.1
Coordinates 65347..65646 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O6D90_RS00310 (61433) 61433..62761 + 1329 WP_016155042.1 MFS transporter -
O6D90_RS00315 (62904) 62904..64295 + 1392 WP_003023929.1 hexose-6-phosphate:phosphate antiporter -
O6D90_RS00320 (64444) 64444..64896 + 453 WP_016157801.1 DUF1198 family protein -
O6D90_RS00325 (64997) 64997..65338 + 342 WP_016157800.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O6D90_RS00330 (65347) 65347..65646 + 300 WP_016157799.1 helix-turn-helix transcriptional regulator Antitoxin
O6D90_RS00335 (65765) 65765..66949 + 1185 WP_016157798.1 purine ribonucleoside efflux pump NepI -
O6D90_RS00340 (67005) 67005..68387 - 1383 WP_016157797.1 glycoside hydrolase family 1 protein -
O6D90_RS00345 (68480) 68480..68773 - 294 WP_016155038.1 YicS family protein -
O6D90_RS00350 (68904) 68904..69320 + 417 WP_016157796.1 GNAT family N-acetyltransferase -
O6D90_RS00355 (69492) 69492..70310 + 819 WP_016157795.1 lipoprotein NlpA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(8-88)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13061.92 Da        Isoelectric Point: 5.6550

>T266842 WP_016157800.1 NZ_CP114801:64997-65338 [Citrobacter sp. 21OH12SH02A-Citro]
MWEVETTDVFDKWFDVQTEALKEDMLAAMMILSEYGPQLGRPFADTVNASAFSNMKELRVQHQGNPIRAFFVFDPSRHGI
VLCAGDKTGLNEKKFYKEMIRLADAEYRNHLNK

Download         Length: 342 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10988.84 Da        Isoelectric Point: 8.6007

>AT266842 WP_016157799.1 NZ_CP114801:65347-65646 [Citrobacter sp. 21OH12SH02A-Citro]
MATLKELMAKQSPESQERIAEKVEVLRQVIALNMLREELNLSQAELASAMGVKQPTIAKMEQADNDPRLSTLKRYVTALG
GELSIDVKLPTGKRVAFHL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6TVT2

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6TWH1

References