Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5790088..5790683 Replicon chromosome
Accession NZ_CP114761
Organism Pseudomonas aeruginosa strain NF143349

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag O4M85_RS27195 Protein ID WP_079752024.1
Coordinates 5790405..5790683 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag O4M85_RS27190 Protein ID WP_083556829.1
Coordinates 5790088..5790393 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O4M85_RS27155 (O4M85_27155) 5785241..5786089 + 849 WP_088376615.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
O4M85_RS27165 (O4M85_27165) 5786256..5787197 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
O4M85_RS27170 (O4M85_27170) 5787314..5787928 + 615 WP_033971050.1 50S ribosomal protein L25/general stress protein Ctc -
O4M85_RS27175 (O4M85_27175) 5787970..5788554 + 585 WP_033971054.1 aminoacyl-tRNA hydrolase -
O4M85_RS27180 (O4M85_27180) 5788595..5789695 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
O4M85_RS27190 (O4M85_27190) 5790088..5790393 - 306 WP_083556829.1 HigA family addiction module antitoxin Antitoxin
O4M85_RS27195 (O4M85_27195) 5790405..5790683 - 279 WP_079752024.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O4M85_RS27200 (O4M85_27200) 5790736..5790962 - 227 Protein_5369 tyrosine-type recombinase/integrase -
O4M85_RS27205 (O4M85_27205) 5791331..5791534 + 204 WP_033971061.1 hypothetical protein -
O4M85_RS27210 (O4M85_27210) 5791950..5792465 - 516 WP_033971063.1 BRO family protein -
O4M85_RS27215 (O4M85_27215) 5792772..5793422 - 651 WP_033971066.1 carbonate dehydratase -
O4M85_RS27220 (O4M85_27220) 5793484..5794722 - 1239 WP_088376614.1 C69 family dipeptidase -
O4M85_RS27225 (O4M85_27225) 5794921..5795373 - 453 WP_088376613.1 ribosomal protein S18-alanine N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10673.26 Da        Isoelectric Point: 8.5538

>T266804 WP_079752024.1 NZ_CP114761:c5790683-5790405 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAAKELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11243.78 Da        Isoelectric Point: 4.7860

>AT266804 WP_083556829.1 NZ_CP114761:c5790393-5790088 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELKISPTALARALNVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References