Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 5057550..5058231 Replicon chromosome
Accession NZ_CP114761
Organism Pseudomonas aeruginosa strain NF143349

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag O4M85_RS23725 Protein ID WP_015503432.1
Coordinates 5057866..5058231 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag O4M85_RS23720 Protein ID WP_016561576.1
Coordinates 5057550..5057873 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O4M85_RS23685 (O4M85_23685) 5053171..5054049 + 879 WP_003109435.1 hypothetical protein -
O4M85_RS23695 (O4M85_23695) 5054561..5055427 - 867 WP_023081971.1 hypothetical protein -
O4M85_RS23700 (O4M85_23700) 5055457..5055708 - 252 WP_124136459.1 hypothetical protein -
O4M85_RS23705 (O4M85_23705) 5055925..5056928 - 1004 Protein_4685 tyrosine-type recombinase/integrase -
O4M85_RS23710 (O4M85_23710) 5056928..5057320 - 393 Protein_4686 hypothetical protein -
O4M85_RS23715 (O4M85_23715) 5057315..5057434 + 120 Protein_4687 IS5/IS1182 family transposase -
O4M85_RS23720 (O4M85_23720) 5057550..5057873 - 324 WP_016561576.1 XRE family transcriptional regulator Antitoxin
O4M85_RS23725 (O4M85_23725) 5057866..5058231 - 366 WP_015503432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O4M85_RS23730 (O4M85_23730) 5058495..5058737 - 243 WP_043884955.1 hypothetical protein -
O4M85_RS23735 (O4M85_23735) 5058944..5059216 + 273 WP_003085667.1 hypothetical protein -
O4M85_RS23740 (O4M85_23740) 5059235..5059660 - 426 WP_003163196.1 VOC family protein -
O4M85_RS23745 (O4M85_23745) 5059761..5060645 + 885 WP_019725847.1 LysR substrate-binding domain-containing protein -
O4M85_RS23750 (O4M85_23750) 5060618..5061571 - 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
O4M85_RS23755 (O4M85_23755) 5061792..5062226 + 435 WP_003158601.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13798.14 Da        Isoelectric Point: 4.8219

>T266802 WP_015503432.1 NZ_CP114761:c5058231-5057866 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRPGHMRELRTQHGGRPFRTLYAFDPRRSA
ILPIGGDKTGDDRWYELNVPIADRLHDEHLHQLREEGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11903.72 Da        Isoelectric Point: 5.8900

>AT266802 WP_016561576.1 NZ_CP114761:c5057873-5057550 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQSRGLSQKMLSEVLQVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References