Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 22099..22634 Replicon plasmid pEF0656-1
Accession NZ_CP114618
Organism Enterococcus faecium strain EF0656

Toxin (Protein)


Gene name yoeB Uniprot ID R2PQC0
Locus tag O4N81_RS13870 Protein ID WP_002314366.1
Coordinates 22362..22634 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q3Y220
Locus tag O4N81_RS13865 Protein ID WP_002297422.1
Coordinates 22099..22362 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O4N81_RS13850 (O4N81_13850) 17527..19776 + 2250 WP_002314387.1 alpha-galactosidase -
O4N81_RS13855 (O4N81_13855) 19779..20954 + 1176 WP_002336205.1 MFS transporter -
O4N81_RS13860 (O4N81_13860) 20957..21865 - 909 Protein_18 IS982-like element ISEfm1 family transposase -
O4N81_RS13865 (O4N81_13865) 22099..22362 + 264 WP_002297422.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
O4N81_RS13870 (O4N81_13870) 22362..22634 + 273 WP_002314366.1 Txe/YoeB family addiction module toxin Toxin
O4N81_RS13875 (O4N81_13875) 22711..23040 + 330 WP_002292678.1 AbrB family transcriptional regulator -
O4N81_RS13880 (O4N81_13880) 23030..23317 + 288 WP_076713767.1 type II toxin-antitoxin system RelE/ParE family toxin -
O4N81_RS13885 (O4N81_13885) 23602..24459 + 858 WP_002292680.1 ParA family protein -
O4N81_RS13890 (O4N81_13890) 24460..25008 + 549 WP_002292681.1 hypothetical protein -
O4N81_RS13895 (O4N81_13895) 25124..26419 - 1296 WP_002297218.1 ISL3-like element ISEfa11 family transposase -
O4N81_RS13900 (O4N81_13900) 26796..27476 + 681 Protein_26 IS6-like element ISS1N family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..149649 149649
- inside IScluster/Tn - - 11498..30879 19381


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10780.24 Da        Isoelectric Point: 9.9724

>T266792 WP_002314366.1 NZ_CP114618:22362-22634 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9959.22 Da        Isoelectric Point: 4.5370

>AT266792 WP_002297422.1 NZ_CP114618:22099-22362 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829F704

Antitoxin

Source ID Structure
AlphaFold DB A0A829F006

References