Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 63302..63566 Replicon plasmid pWEC-2
Accession NZ_CP114594
Organism Escherichia coli strain WEC

Toxin (Protein)


Gene name pndA Uniprot ID A0A8H9BDR8
Locus tag O3296_RS23685 Protein ID WP_023156060.1
Coordinates 63414..63566 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 63302..63359 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O3296_RS23670 (58415) 58415..59626 - 1212 WP_021560355.1 DsbC family protein -
O3296_RS23675 (59701) 59701..60894 - 1194 WP_053285742.1 hypothetical protein -
O3296_RS23680 (60910) 60910..63123 - 2214 WP_021560353.1 type IA DNA topoisomerase -
- (63302) 63302..63359 - 58 NuclAT_0 - Antitoxin
- (63302) 63302..63359 - 58 NuclAT_0 - Antitoxin
- (63302) 63302..63359 - 58 NuclAT_0 - Antitoxin
- (63302) 63302..63359 - 58 NuclAT_0 - Antitoxin
O3296_RS23685 (63414) 63414..63566 + 153 WP_023156060.1 Hok/Gef family protein Toxin
O3296_RS23690 (63638) 63638..63889 - 252 WP_001685192.1 hypothetical protein -
O3296_RS23695 (64093) 64093..64299 + 207 WP_064550069.1 DinQ-like type I toxin DqlB -
O3296_RS23700 (64405) 64405..65358 - 954 WP_143368613.1 hypothetical protein -
O3296_RS23705 (65427) 65427..67571 - 2145 WP_021560351.1 DotA/TraY family protein -
O3296_RS23710 (67606) 67606..67830 - 225 WP_021560350.1 hypothetical protein -
O3296_RS23715 (67833) 67833..68396 - 564 WP_021560349.1 conjugal transfer protein TraX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..92065 92065


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5809.14 Da        Isoelectric Point: 8.7948

>T266780 WP_023156060.1 NZ_CP114594:63414-63566 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGFRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T266780 NZ_CP114594:63414-63566 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGATTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 58 bp

>AT266780 NZ_CP114594:c63359-63302 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References