Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | HipBST/HipA(toxin) |
Location | 2747705..2748948 | Replicon | chromosome |
Accession | NZ_CP114578 | ||
Organism | Legionella pneumophila strain A194 |
Toxin (Protein)
Gene name | HipT | Uniprot ID | - |
Locus tag | LpnA194_RS12270 | Protein ID | WP_040146471.1 |
Coordinates | 2748010..2748948 (+) | Length | 313 a.a. |
Antitoxin (Protein)
Gene name | HipS | Uniprot ID | A0A378KAQ5 |
Locus tag | LpnA194_RS12265 | Protein ID | WP_013101793.1 |
Coordinates | 2747705..2748013 (+) | Length | 103 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LpnA194_RS12230 (LpnA194_02456) | 2743177..2744037 | + | 861 | WP_011947276.1 | DUF2608 domain-containing protein | - |
LpnA194_RS12235 (LpnA194_02457) | 2744387..2744650 | - | 264 | WP_229293899.1 | hypothetical protein | - |
LpnA194_RS12240 (LpnA194_02458) | 2744697..2745008 | - | 312 | WP_011947278.1 | cupin | - |
LpnA194_RS12245 (LpnA194_02459) | 2745024..2745281 | - | 258 | WP_027219384.1 | hypothetical protein | - |
LpnA194_RS12250 (LpnA194_02460) | 2745457..2745930 | + | 474 | WP_011947280.1 | hypothetical protein | - |
LpnA194_RS12255 (LpnA194_02461) | 2746120..2747037 | + | 918 | WP_011947281.1 | LysR family transcriptional regulator | - |
LpnA194_RS12260 (LpnA194_02462) | 2747481..2747708 | + | 228 | WP_013101792.1 | helix-turn-helix transcriptional regulator | - |
LpnA194_RS12265 (LpnA194_02463) | 2747705..2748013 | + | 309 | WP_013101793.1 | HipA N-terminal domain-containing protein | Antitoxin |
LpnA194_RS12270 (LpnA194_02464) | 2748010..2748948 | + | 939 | WP_040146471.1 | HipA domain-containing protein | Toxin |
LpnA194_RS12275 (LpnA194_02465) | 2749111..2749821 | - | 711 | WP_013101794.1 | outer membrane beta-barrel protein | - |
LpnA194_RS12280 (LpnA194_02466) | 2750305..2750598 | - | 294 | WP_027219386.1 | SNARE domain-containing protein | - |
LpnA194_RS12285 (LpnA194_02467) | 2750626..2751525 | - | 900 | WP_011947287.1 | hypothetical protein | - |
LpnA194_RS12290 (LpnA194_02468) | 2751688..2753142 | + | 1455 | WP_027219387.1 | lpg2382 family Dot/Icm T4SS effector | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 313 a.a. Molecular weight: 36062.75 Da Isoelectric Point: 9.4783
>T266741 WP_040146471.1 NZ_CP114578:2748010-2748948 [Legionella pneumophila]
MKRCPITYEKISDQENYSQRGLRLLSPQLKNLSPLDLSADEQRQEAIARVGKTSIQGVQKKLSAKLKIKEGCFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAIIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITRDRKISISPAYDLLNSTIAQKNTKEEIALLLKG
KKNNLTKSVFFNYFAVEKLGLNQNVINGIAQEFHQAIPEWRELISFSFLSQPMQEKYLQLLDQRCKRLNFFD
MKRCPITYEKISDQENYSQRGLRLLSPQLKNLSPLDLSADEQRQEAIARVGKTSIQGVQKKLSAKLKIKEGCFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAIIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITRDRKISISPAYDLLNSTIAQKNTKEEIALLLKG
KKNNLTKSVFFNYFAVEKLGLNQNVINGIAQEFHQAIPEWRELISFSFLSQPMQEKYLQLLDQRCKRLNFFD
Download Length: 939 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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