Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2747705..2748948 Replicon chromosome
Accession NZ_CP114578
Organism Legionella pneumophila strain A194

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag LpnA194_RS12270 Protein ID WP_040146471.1
Coordinates 2748010..2748948 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A378KAQ5
Locus tag LpnA194_RS12265 Protein ID WP_013101793.1
Coordinates 2747705..2748013 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LpnA194_RS12230 (LpnA194_02456) 2743177..2744037 + 861 WP_011947276.1 DUF2608 domain-containing protein -
LpnA194_RS12235 (LpnA194_02457) 2744387..2744650 - 264 WP_229293899.1 hypothetical protein -
LpnA194_RS12240 (LpnA194_02458) 2744697..2745008 - 312 WP_011947278.1 cupin -
LpnA194_RS12245 (LpnA194_02459) 2745024..2745281 - 258 WP_027219384.1 hypothetical protein -
LpnA194_RS12250 (LpnA194_02460) 2745457..2745930 + 474 WP_011947280.1 hypothetical protein -
LpnA194_RS12255 (LpnA194_02461) 2746120..2747037 + 918 WP_011947281.1 LysR family transcriptional regulator -
LpnA194_RS12260 (LpnA194_02462) 2747481..2747708 + 228 WP_013101792.1 helix-turn-helix transcriptional regulator -
LpnA194_RS12265 (LpnA194_02463) 2747705..2748013 + 309 WP_013101793.1 HipA N-terminal domain-containing protein Antitoxin
LpnA194_RS12270 (LpnA194_02464) 2748010..2748948 + 939 WP_040146471.1 HipA domain-containing protein Toxin
LpnA194_RS12275 (LpnA194_02465) 2749111..2749821 - 711 WP_013101794.1 outer membrane beta-barrel protein -
LpnA194_RS12280 (LpnA194_02466) 2750305..2750598 - 294 WP_027219386.1 SNARE domain-containing protein -
LpnA194_RS12285 (LpnA194_02467) 2750626..2751525 - 900 WP_011947287.1 hypothetical protein -
LpnA194_RS12290 (LpnA194_02468) 2751688..2753142 + 1455 WP_027219387.1 lpg2382 family Dot/Icm T4SS effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-279)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36062.75 Da        Isoelectric Point: 9.4783

>T266741 WP_040146471.1 NZ_CP114578:2748010-2748948 [Legionella pneumophila]
MKRCPITYEKISDQENYSQRGLRLLSPQLKNLSPLDLSADEQRQEAIARVGKTSIQGVQKKLSAKLKIKEGCFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAIIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITRDRKISISPAYDLLNSTIAQKNTKEEIALLLKG
KKNNLTKSVFFNYFAVEKLGLNQNVINGIAQEFHQAIPEWRELISFSFLSQPMQEKYLQLLDQRCKRLNFFD

Download         Length: 939 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11586.38 Da        Isoelectric Point: 4.5859

>AT266741 WP_013101793.1 NZ_CP114578:2747705-2748013 [Legionella pneumophila]
MRKAYVSVNGIKAGILEELQSGKYQFSYFDDYHGAPVSLTMPLTNKVYDFDVFPPFFEGLLPEGIMIEALLRKYKIDKND
YFGQLIIVGQDVVGAVTIEEIR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A378KAQ5

References