Detailed information of TA system TA026674

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1753097..1753676
• Replicon: chromosome
• Accession: NC_017342
• Organism: Staphylococcus aureus subsp. aureus TCH60

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: HMPREF0772_RS08910
• Protein ID: WP_001025401.1
• Coordinates: 1753097..1753342 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1753311..1753676 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMPREF0772_RS08865	1749115..1749729	+	615	WP_000191459.1	hypothetical protein	-
HMPREF0772_RS08870	1749726..1749872	-	147	WP_001013104.1	hypothetical protein	-
HMPREF0772_RS08875	1750102..1750686	-	585	WP_000825948.1	hypothetical protein	-
HMPREF0772_RS08880	1750704..1751165	-	462	WP_000525004.1	hypothetical protein	-
HMPREF0772_RS08885	1751178..1751492	-	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
HMPREF0772_RS08890	1751644..1751880	+	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
HMPREF0772_RS08895	1751894..1752670	+	777	WP_001148544.1	Rha family transcriptional regulator	-
HMPREF0772_RS08900	1752699..1752842	+	144	WP_000939498.1	hypothetical protein	-
HMPREF0772_RS08905	1752832..1753041	-	210	WP_000642492.1	hypothetical protein	-
HMPREF0772_RS08910	1753097..1753342	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
HMPREF0772_RS08915	1753311..1753676	-	366	WP_001128433.1	hypothetical protein	Antitoxin
HMPREF0772_RS08920	1753731..1753946	+	216	WP_001036302.1	hypothetical protein	-
HMPREF0772_RS08925	1753971..1754234	+	264	WP_001124190.1	helix-turn-helix domain-containing protein	-
HMPREF0772_RS08930	1754247..1754408	+	162	WP_001285963.1	DUF1270 family protein	-
HMPREF0772_RS08935	1754487..1754810	+	324	WP_000175000.1	hypothetical protein	-
HMPREF0772_RS08940	1754825..1755187	+	363	WP_000279449.1	hypothetical protein	-
HMPREF0772_RS08945	1755184..1756350	+	1167	WP_000762532.1	DUF2800 domain-containing protein	-
HMPREF0772_RS08950	1756376..1756933	+	558	WP_000645042.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukS-PV / lukF-PV	1744780..1793870	49090

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T26674 WP_001025401.1 NC_017342:1753097-1753342 [Staphylococcus aureus subsp. aureus TCH60]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T26674 NC_017342:1753097-1753342 [Staphylococcus aureus subsp. aureus TCH60]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAGGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT26674 NC_017342:c1753676-1753311 [Staphylococcus aureus subsp. aureus TCH60]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin