Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_31
Location 84383..84987 Replicon chromosome
Accession NZ_CP114578
Organism Legionella pneumophila strain A194

Toxin (Protein)


Gene name higB Uniprot ID A0A128WF47
Locus tag LpnA194_RS00405 Protein ID WP_011212715.1
Coordinates 84383..84706 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LpnA194_RS00410 Protein ID WP_044499250.1
Coordinates 84703..84987 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LpnA194_RS00380 (LpnA194_00076) 79530..80834 + 1305 WP_040147085.1 ATP-grasp domain-containing protein -
LpnA194_RS00385 (LpnA194_00077) 80855..81445 + 591 WP_011945268.1 alpha/beta hydrolase -
LpnA194_RS00390 (LpnA194_00078) 81429..82376 + 948 WP_011945269.1 DMT family transporter -
LpnA194_RS00395 (LpnA194_00079) 82476..82823 + 348 Protein_78 transposase family protein -
LpnA194_RS00400 (LpnA194_00080) 83079..84299 + 1221 WP_044499247.1 site-specific integrase -
LpnA194_RS00405 (LpnA194_00081) 84383..84706 + 324 WP_011212715.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LpnA194_RS00410 (LpnA194_00082) 84703..84987 + 285 WP_044499250.1 helix-turn-helix transcriptional regulator Antitoxin
LpnA194_RS00415 (LpnA194_00083) 85181..85984 + 804 WP_229293969.1 hypothetical protein -
LpnA194_RS00420 (LpnA194_00084) 86748..88160 - 1413 WP_044499254.1 hypothetical protein -
LpnA194_RS00425 (LpnA194_00085) 88191..88799 - 609 WP_011945275.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 82476..82853 377


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-86)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12144.36 Da        Isoelectric Point: 9.7878

>T266739 WP_011212715.1 NZ_CP114578:84383-84706 [Legionella pneumophila]
MSWIVEFYNESVEEAILTMPPKIQARMIKLLELIETHGANLGPPHTEAMGDGLFEIRAKAQEGIGRSLYCYMKGKHIVVL
HAFVKKSAKTPKPDLQLALKRKREVEK

Download         Length: 324 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10517.26 Da        Isoelectric Point: 10.1029

>AT266739 WP_044499250.1 NZ_CP114578:84703-84987 [Legionella pneumophila]
MMKLKTLKAKALKNPEVKEAYDALESEFALINTLLTMRQKAGLTQEELAERMGTKKGNISRLEKGNTNPSWNTLEKYAHA
CGFDISMAVKRIAS

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A128WF47

Antitoxin

Source ID Structure

References