266737

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 2867907..2869150 Replicon chromosome
Accession NZ_CP114576
Organism Legionella pneumophila strain H3

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag LpnH3D14_RS12975 Protein ID WP_011947284.1
Coordinates 2868212..2869150 (+) Length 313 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A378KAQ5
Locus tag LpnH3D14_RS12970 Protein ID WP_013101793.1
Coordinates 2867907..2868215 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LpnH3D14_RS12935 (LpnH3D14_02602) 2863379..2864239 + 861 WP_011947276.1 DUF2608 domain-containing protein -
LpnH3D14_RS12940 (LpnH3D14_02603) 2864589..2864888 - 300 WP_013101791.1 hypothetical protein -
LpnH3D14_RS12945 (LpnH3D14_02604) 2864899..2865210 - 312 WP_011947278.1 cupin -
LpnH3D14_RS12950 (LpnH3D14_02605) 2865226..2865483 - 258 WP_042646098.1 hypothetical protein -
LpnH3D14_RS12955 (LpnH3D14_02606) 2865659..2866132 + 474 WP_011947280.1 hypothetical protein -
LpnH3D14_RS12960 (LpnH3D14_02607) 2866322..2867239 + 918 WP_011947281.1 LysR family transcriptional regulator -
LpnH3D14_RS12965 (LpnH3D14_02608) 2867683..2867910 + 228 WP_013101792.1 helix-turn-helix transcriptional regulator -
LpnH3D14_RS12970 (LpnH3D14_02609) 2867907..2868215 + 309 WP_013101793.1 HipA N-terminal domain-containing protein Antitoxin
LpnH3D14_RS12975 (LpnH3D14_02610) 2868212..2869150 + 939 WP_011947284.1 HipA domain-containing protein Toxin
LpnH3D14_RS12980 (LpnH3D14_02611) 2869237..2870433 - 1197 WP_040185993.1 IS4-like element ISLpn1 family transposase -
LpnH3D14_RS12985 (LpnH3D14_02612) 2870678..2871388 - 711 WP_269565258.1 outer membrane beta-barrel protein -
LpnH3D14_RS12990 (LpnH3D14_02613) 2871871..2872164 - 294 WP_011947286.1 SNARE domain-containing protein -
LpnH3D14_RS12995 (LpnH3D14_02614) 2872192..2873091 - 900 WP_013101795.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2869237..2870433 1196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-279)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 36078.70 Da        Isoelectric Point: 9.3347

>T266737 WP_011947284.1 NZ_CP114576:2868212-2869150 [Legionella pneumophila]
MKRCPITYEKISDQENYSQRGLRLLSPQLKNLSPLDLSADEQRQEAIARVGKTSIQGVQKKLSAKLKIKEGCFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAIIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITRDRKISISPAYDLLNSTIAQKNTKEEIALLLKG
KKNNLTKSDFFNYFAVEKLGLNQNVINGIAQEFHQAIPEWRELISFSFLSQPMQEKYLQLLDQRCKRLNFFD

Download         Length: 939 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11586.38 Da        Isoelectric Point: 4.5859

>AT266737 WP_013101793.1 NZ_CP114576:2867907-2868215 [Legionella pneumophila]
MRKAYVSVNGIKAGILEELQSGKYQFSYFDDYHGAPVSLTMPLTNKVYDFDVFPPFFEGLLPEGIMIEALLRKYKIDKND
YFGQLIIVGQDVVGAVTIEEIR

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A378KAQ5

References