Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3648724..3649399 Replicon chromosome
Accession NZ_CP114571
Organism Enterobacter hormaechei strain E1532

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag O2601_RS17790 Protein ID WP_032619177.1
Coordinates 3648724..3649023 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2J0PXC9
Locus tag O2601_RS17795 Protein ID WP_015571639.1
Coordinates 3649034..3649399 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O2601_RS17770 (O2601_17770) 3643856..3644473 - 618 WP_032634496.1 DUF1819 family protein -
O2601_RS17775 (O2601_17775) 3644637..3645605 - 969 WP_080288382.1 IS5-like element IS903B family transposase -
O2601_RS17780 (O2601_17780) 3645668..3647293 + 1626 WP_230199853.1 ATP-binding cassette domain-containing protein -
O2601_RS17785 (O2601_17785) 3647274..3648473 + 1200 WP_017382757.1 HlyD family efflux transporter periplasmic adaptor subunit -
O2601_RS17790 (O2601_17790) 3648724..3649023 + 300 WP_032619177.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O2601_RS17795 (O2601_17795) 3649034..3649399 + 366 WP_015571639.1 HigA family addiction module antitoxin Antitoxin
O2601_RS17800 (O2601_17800) 3649426..3650607 - 1182 WP_032619175.1 PLP-dependent aminotransferase family protein -
O2601_RS17805 (O2601_17805) 3650628..3651515 - 888 WP_032619173.1 LysR family transcriptional regulator -
O2601_RS17810 (O2601_17810) 3651613..3652215 + 603 WP_017382759.1 short chain dehydrogenase -
O2601_RS17815 (O2601_17815) 3652212..3652943 - 732 WP_017382760.1 methyltransferase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3644637..3670354 25717
- flank IS/Tn - - 3644637..3645605 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11564.19 Da        Isoelectric Point: 9.6776

>T266730 WP_032619177.1 NZ_CP114571:3648724-3649023 [Enterobacter hormaechei]
MINHSRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13705.73 Da        Isoelectric Point: 9.5936

>AT266730 WP_015571639.1 NZ_CP114571:3649034-3649399 [Enterobacter hormaechei]
MTLQQALRKPTTPGEVLQYEYLEPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVTLHGNSA

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J0PXC9

References