Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 36484..37214 Replicon chromosome
Accession NZ_CP114571
Organism Enterobacter hormaechei strain E1532

Toxin (Protein)


Gene name higB Uniprot ID A0A837FIL2
Locus tag O2601_RS00170 Protein ID WP_023302825.1
Coordinates 36484..36798 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag O2601_RS00175 Protein ID WP_032620773.1
Coordinates 36798..37214 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O2601_RS00150 (O2601_00150) 32150..33235 + 1086 Protein_29 cellulase family glycosylhydrolase -
O2601_RS00155 (O2601_00155) 33141..34325 - 1185 WP_015570118.1 multidrug efflux MFS transporter EmrD -
O2601_RS00160 (O2601_00160) 34501..35334 - 834 WP_032620535.1 DMT family transporter -
O2601_RS00165 (O2601_00165) 35397..35843 - 447 WP_003861064.1 GNAT family N-acetyltransferase -
O2601_RS00170 (O2601_00170) 36484..36798 + 315 WP_023302825.1 type II toxin-antitoxin system HigB family toxin Toxin
O2601_RS00175 (O2601_00175) 36798..37214 + 417 WP_032620773.1 helix-turn-helix domain-containing protein Antitoxin
O2601_RS00180 (O2601_00180) 37361..37459 + 99 WP_057979964.1 ilvB operon leader peptide IvbL -
O2601_RS00185 (O2601_00185) 37566..39254 + 1689 WP_023302827.1 acetolactate synthase large subunit -
O2601_RS00190 (O2601_00190) 39258..39545 + 288 WP_015570113.1 acetolactate synthase small subunit -
O2601_RS00195 (O2601_00195) 39671..40264 + 594 WP_003861054.1 transcriptional regulator UhpA -
O2601_RS00200 (O2601_00200) 40261..41766 + 1506 WP_032634219.1 signal transduction histidine-protein kinase/phosphatase UhpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-136)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12415.51 Da        Isoelectric Point: 10.2825

>T266721 WP_023302825.1 NZ_CP114571:36484-36798 [Enterobacter hormaechei]
MHLISMKAILDAVSQFPQHREELLFLGRVIEKSHCPTPAALRKLFPTLDNFKYLDKHYVIDIANNNLRVVALIFFESQKF
YVRHVFTHKEYDRFTEKHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15249.77 Da        Isoelectric Point: 5.2068

>AT266721 WP_032620773.1 NZ_CP114571:36798-37214 [Enterobacter hormaechei]
MIVADAMKATHALVAAVPLLGEQPSEKDYKDALELVEYLLMNEPNSPLLDIVCARISHYEANGPEIVALRKEMESVPVGI
AVLRTLMDQYNLTISDFKDEIGSKSMVSRVLNGQRQLTLNHIKKLAARFGVSPALFIE

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FIL2

Antitoxin

Source ID Structure

References