Detailed information of TA system TA026667

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1268208..1268546
• Replicon: chromosome
• Accession: NC_017342
• Organism: Staphylococcus aureus subsp. aureus TCH60

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: HMPREF0772_RS14560
• Protein ID: WP_011447039.1
• Coordinates: 1268208..1268384 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1268372..1268546 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HMPREF0772_RS06245	1263443..1267228	+	3786	WP_000582167.1	hypothetical protein	-
HMPREF0772_RS06250	1267218..1267370	+	153	WP_001153681.1	hypothetical protein	-
HMPREF0772_RS06255	1267417..1267704	+	288	WP_001040261.1	hypothetical protein	-
HMPREF0772_RS06260	1267762..1268058	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
HMPREF0772_RS14560	1268208..1268384	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	1268372..1268546	-	175	-	-	Antitoxin
HMPREF0772_RS06275	1268596..1268850	+	255	WP_000611512.1	phage holin	-
HMPREF0772_RS06280	1268862..1269617	+	756	WP_000861038.1	CHAP domain-containing protein	-
HMPREF0772_RS06285	1269807..1270298	+	492	WP_000919350.1	staphylokinase	-
HMPREF0772_RS15100	1270948..1271283	+	336	Protein_1191	SH3 domain-containing protein	-
HMPREF0772_RS06295	1271378..1271827	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
HMPREF0772_RS06300	1272511..1272861	+	351	WP_000702263.1	complement inhibitor SCIN-A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL / hlb / sak / chp / scn	1244469..1274531	30062
	-	flank	IS/Tn	-	-	1272885..1274531	1646

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T26667 WP_011447039.1 NC_017342:1268208-1268384 [Staphylococcus aureus subsp. aureus TCH60]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T26667 NC_017342:1268208-1268384 [Staphylococcus aureus subsp. aureus TCH60]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT26667 NC_017342:c1268546-1268372 [Staphylococcus aureus subsp. aureus TCH60]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin