Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 733458..734233 Replicon chromosome
Accession NZ_CP114375
Organism Klebsiella pneumoniae strain KP6870155

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A332L402
Locus tag NOZ09_RS03640 Protein ID WP_021314147.1
Coordinates 733748..734233 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag NOZ09_RS03635 Protein ID WP_004150912.1
Coordinates 733458..733751 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOZ09_RS03615 (728666) 728666..729268 - 603 WP_002916735.1 short chain dehydrogenase -
NOZ09_RS03620 (729366) 729366..730277 + 912 WP_004188550.1 LysR family transcriptional regulator -
NOZ09_RS03625 (730278) 730278..731426 - 1149 WP_032417597.1 PLP-dependent aspartate aminotransferase family protein -
NOZ09_RS03630 (731437) 731437..732813 - 1377 WP_073553579.1 cystathionine beta-synthase -
NOZ09_RS03635 (733458) 733458..733751 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
NOZ09_RS03640 (733748) 733748..734233 + 486 WP_021314147.1 GNAT family N-acetyltransferase Toxin
NOZ09_RS03645 (734937) 734937..735530 + 594 WP_004188553.1 hypothetical protein -
NOZ09_RS03650 (735627) 735627..735843 + 217 Protein_717 transposase -
NOZ09_RS03660 (736358) 736358..737071 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 735627..735779 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17621.68 Da        Isoelectric Point: 8.5144

>T266642 WP_021314147.1 NZ_CP114375:733748-734233 [Klebsiella pneumoniae]
MILAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT266642 WP_004150912.1 NZ_CP114375:733458-733751 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332L402

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References