Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 363371..364017 Replicon chromosome
Accession NZ_CP114375
Organism Klebsiella pneumoniae strain KP6870155

Toxin (Protein)


Gene name higB Uniprot ID A0A231WWF9
Locus tag NOZ09_RS01690 Protein ID WP_004174016.1
Coordinates 363371..363718 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4S7L580
Locus tag NOZ09_RS01695 Protein ID WP_019725405.1
Coordinates 363718..364017 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NOZ09_RS01680 (359297) 359297..360730 + 1434 WP_032445350.1 glycogen synthase GlgA -
NOZ09_RS01685 (360748) 360748..363195 + 2448 WP_002920561.1 glycogen phosphorylase -
NOZ09_RS01690 (363371) 363371..363718 + 348 WP_004174016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NOZ09_RS01695 (363718) 363718..364017 + 300 WP_019725405.1 XRE family transcriptional regulator Antitoxin
NOZ09_RS01700 (364080) 364080..365588 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
NOZ09_RS01705 (365793) 365793..366122 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
NOZ09_RS01710 (366173) 366173..367003 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
NOZ09_RS01715 (367053) 367053..367811 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13518.55 Da        Isoelectric Point: 6.2327

>T266641 WP_004174016.1 NZ_CP114375:363371-363718 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10775.53 Da        Isoelectric Point: 9.7681

>AT266641 WP_019725405.1 NZ_CP114375:363718-364017 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKSYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A231WWF9

Antitoxin

Source ID Structure
AlphaFold DB A0A4S7L580

References