Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4853057..4853738 Replicon chromosome
Accession NZ_CP114374
Organism Pseudomonas aeruginosa strain Jade-X

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag O2604_RS22865 Protein ID WP_096255097.1
Coordinates 4853373..4853738 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1C7BMJ2
Locus tag O2604_RS22860 Protein ID WP_003159602.1
Coordinates 4853057..4853380 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O2604_RS22835 (O2604_22835) 4848330..4849271 - 942 WP_003085798.1 alpha/beta hydrolase -
O2604_RS22840 (O2604_22840) 4849380..4850063 - 684 WP_124715685.1 TetR/AcrR family transcriptional regulator -
O2604_RS22845 (O2604_22845) 4850151..4851029 + 879 WP_023120826.1 hypothetical protein -
O2604_RS22855 (O2604_22855) 4851813..4852975 + 1163 WP_149586497.1 IS3-like element IS222 family transposase -
O2604_RS22860 (O2604_22860) 4853057..4853380 - 324 WP_003159602.1 XRE family transcriptional regulator Antitoxin
O2604_RS22865 (O2604_22865) 4853373..4853738 - 366 WP_096255097.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O2604_RS22870 (O2604_22870) 4854031..4854273 - 243 WP_042115131.1 hypothetical protein -
O2604_RS22875 (O2604_22875) 4854480..4854752 + 273 WP_003085667.1 hypothetical protein -
O2604_RS22880 (O2604_22880) 4854771..4855196 - 426 WP_003114206.1 VOC family protein -
O2604_RS22885 (O2604_22885) 4855297..4856181 + 885 WP_009875989.1 LysR family transcriptional regulator -
O2604_RS22890 (O2604_22890) 4856154..4857107 - 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
O2604_RS22895 (O2604_22895) 4857328..4857762 + 435 WP_003158601.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13897.27 Da        Isoelectric Point: 4.7017

>T266638 WP_096255097.1 NZ_CP114374:c4853738-4853373 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHLHSSGINGSRHGHMRELRTQHGGRPFRTLYAFDPRRSA
ILLIGGDKTGDDRWYELDVPIADRLYDEHLHQLREEGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11882.71 Da        Isoelectric Point: 6.4751

>AT266638 WP_003159602.1 NZ_CP114374:c4853380-4853057 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEGQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLHVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BMJ2

References