Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4165832..4166429 Replicon chromosome
Accession NZ_CP114361
Organism Klebsiella variicola strain 2022CK-00568

Toxin (Protein)


Gene name higB Uniprot ID A0A0B7GEF2
Locus tag OPU52_RS20290 Protein ID WP_012542526.1
Coordinates 4166112..4166429 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OPU52_RS20285 Protein ID WP_012542525.1
Coordinates 4165832..4166119 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OPU52_RS20255 (OPU52_20250) 4161736..4161984 + 249 WP_008805539.1 DUF1158 domain-containing protein -
OPU52_RS20260 (OPU52_20255) 4162001..4162342 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
OPU52_RS20265 (OPU52_20260) 4162373..4163488 - 1116 WP_162823038.1 MBL fold metallo-hydrolase -
OPU52_RS20270 (OPU52_20265) 4163668..4164249 + 582 WP_012968754.1 TetR/AcrR family transcriptional regulator -
OPU52_RS20275 (OPU52_20270) 4164249..4164617 + 369 WP_008805536.1 MmcQ/YjbR family DNA-binding protein -
OPU52_RS20280 (OPU52_20275) 4164737..4165390 + 654 WP_032729541.1 oxygen-insensitive NAD(P)H nitroreductase -
OPU52_RS20285 (OPU52_20280) 4165832..4166119 - 288 WP_012542525.1 helix-turn-helix transcriptional regulator Antitoxin
OPU52_RS20290 (OPU52_20285) 4166112..4166429 - 318 WP_012542526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OPU52_RS20295 (OPU52_20290) 4166614..4167657 - 1044 WP_269136554.1 DUF2157 domain-containing protein -
OPU52_RS20300 (OPU52_20295) 4168122..4168988 - 867 WP_008805530.1 helix-turn-helix transcriptional regulator -
OPU52_RS20305 (OPU52_20300) 4169097..4170524 + 1428 WP_023297179.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-89)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12092.35 Da        Isoelectric Point: 11.2767

>T266621 WP_012542526.1 NZ_CP114361:c4166429-4166112 [Klebsiella variicola]
IFRLVVHVDVKKELQALPPIVQAKMIRQIDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10815.51 Da        Isoelectric Point: 10.2212

>AT266621 WP_012542525.1 NZ_CP114361:c4166119-4165832 [Klebsiella variicola]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQILLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7GEF2

Antitoxin

Source ID Structure

References