Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 368554..369200 Replicon chromosome
Accession NZ_CP114361
Organism Klebsiella variicola strain 2022CK-00568

Toxin (Protein)


Gene name higB Uniprot ID A0A2V3KK24
Locus tag OPU52_RS01685 Protein ID WP_032731351.1
Coordinates 368554..368901 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1F2LZT5
Locus tag OPU52_RS01690 Protein ID WP_008806992.1
Coordinates 368901..369200 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OPU52_RS01675 (OPU52_01675) 364441..365874 + 1434 WP_004202133.1 glycogen synthase GlgA -
OPU52_RS01680 (OPU52_01680) 365892..368339 + 2448 WP_048268278.1 glycogen phosphorylase -
OPU52_RS01685 (OPU52_01685) 368554..368901 + 348 WP_032731351.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OPU52_RS01690 (OPU52_01690) 368901..369200 + 300 WP_008806992.1 XRE family transcriptional regulator Antitoxin
OPU52_RS01695 (OPU52_01695) 369263..370771 - 1509 WP_032740278.1 glycerol-3-phosphate dehydrogenase -
OPU52_RS01700 (OPU52_01700) 370976..371305 + 330 WP_004202138.1 thiosulfate sulfurtransferase GlpE -
OPU52_RS01705 (OPU52_01705) 371356..372186 + 831 WP_008806994.1 rhomboid family intramembrane serine protease GlpG -
OPU52_RS01710 (OPU52_01710) 372236..372994 + 759 WP_008806995.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13474.43 Da        Isoelectric Point: 6.2327

>T266611 WP_032731351.1 NZ_CP114361:368554-368901 [Klebsiella variicola]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFGPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKETITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10814.61 Da        Isoelectric Point: 10.1464

>AT266611 WP_008806992.1 NZ_CP114361:368901-369200 [Klebsiella variicola]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V3KK24

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2LZT5

References