Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1287..1884 Replicon plasmid unnamed4
Accession NZ_CP114358
Organism Klebsiella variicola strain 2022CK-00567

Toxin (Protein)


Gene name higB Uniprot ID A0A0B7GEF2
Locus tag OPU51_RS29325 Protein ID WP_012542526.1
Coordinates 1287..1604 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OPU51_RS29330 Protein ID WP_012542525.1
Coordinates 1597..1884 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OPU51_RS29320 (OPU51_29320) 59..1102 + 1044 WP_269136554.1 DUF2157 domain-containing protein -
OPU51_RS29325 (OPU51_29325) 1287..1604 + 318 WP_012542526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OPU51_RS29330 (OPU51_29330) 1597..1884 + 288 WP_012542525.1 helix-turn-helix transcriptional regulator Antitoxin
OPU51_RS29335 (OPU51_29335) 2326..2979 - 654 WP_032729541.1 oxygen-insensitive NAD(P)H nitroreductase -
OPU51_RS29340 (OPU51_29340) 3099..3467 - 369 WP_008805536.1 MmcQ/YjbR family DNA-binding protein -
OPU51_RS29345 (OPU51_29345) 3467..4048 - 582 WP_012968754.1 TetR/AcrR family transcriptional regulator -
OPU51_RS29350 (OPU51_29350) 4228..5343 + 1116 WP_162823038.1 MBL fold metallo-hydrolase -
OPU51_RS29355 (OPU51_29355) 5374..5715 + 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
OPU51_RS29360 (OPU51_29360) 5732..5980 - 249 WP_008805539.1 DUF1158 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..33141 33141


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-89)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12092.35 Da        Isoelectric Point: 11.2767

>T266608 WP_012542526.1 NZ_CP114358:1287-1604 [Klebsiella variicola]
IFRLVVHVDVKKELQALPPIVQAKMIRQIDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10815.51 Da        Isoelectric Point: 10.2212

>AT266608 WP_012542525.1 NZ_CP114358:1597-1884 [Klebsiella variicola]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQILLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7GEF2

Antitoxin

Source ID Structure

References