Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 856820..857337 Replicon chromosome
Accession NC_017342
Organism Staphylococcus aureus subsp. aureus TCH60

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag HMPREF0772_RS04125 Protein ID WP_000251928.1
Coordinates 857071..857337 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag HMPREF0772_RS04120 Protein ID WP_000584497.1
Coordinates 856820..857071 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMPREF0772_RS04090 852520..853239 + 720 WP_000479573.1 amino acid ABC transporter permease -
HMPREF0772_RS04095 853236..853967 + 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
HMPREF0772_RS04100 854064..855314 - 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
HMPREF0772_RS04105 855569..855931 + 363 WP_000819843.1 DUF4467 domain-containing protein -
HMPREF0772_RS04110 855950..856549 + 600 WP_000162804.1 DsbA family protein -
HMPREF0772_RS04115 856556..856656 + 101 Protein_776 hypothetical protein -
HMPREF0772_RS04120 856820..857071 + 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HMPREF0772_RS04125 857071..857337 + 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
HMPREF0772_RS04130 857630..859177 + 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
HMPREF0772_RS04135 859363..859830 + 468 WP_000153340.1 SRPBCC domain-containing protein -
HMPREF0772_RS04140 859917..860099 + 183 WP_000079140.1 hypothetical protein -
HMPREF0772_RS04145 860302..861126 + 825 WP_000594640.1 formate/nitrite transporter family protein -
HMPREF0772_RS04150 861594..862130 + 537 WP_000024292.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T26660 WP_000251928.1 NC_017342:857071-857337 [Staphylococcus aureus subsp. aureus TCH60]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T26660 NC_017342:857071-857337 [Staphylococcus aureus subsp. aureus TCH60]
ATGGTTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTAATTAAAAGTATTGACAGAAATGGTGCGTTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT26660 WP_000584497.1 NC_017342:856820-857071 [Staphylococcus aureus subsp. aureus TCH60]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT26660 NC_017342:856820-857071 [Staphylococcus aureus subsp. aureus TCH60]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATAGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTGTAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References