Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 368555..369201 Replicon chromosome
Accession NZ_CP114354
Organism Klebsiella variicola strain 2022CK-00567

Toxin (Protein)


Gene name higB Uniprot ID A0A2V3KK24
Locus tag OPU51_RS01685 Protein ID WP_032731351.1
Coordinates 368555..368902 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1F2LZT5
Locus tag OPU51_RS01690 Protein ID WP_008806992.1
Coordinates 368902..369201 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OPU51_RS01675 (OPU51_01675) 364442..365875 + 1434 WP_004202133.1 glycogen synthase GlgA -
OPU51_RS01680 (OPU51_01680) 365893..368340 + 2448 WP_048268278.1 glycogen phosphorylase -
OPU51_RS01685 (OPU51_01685) 368555..368902 + 348 WP_032731351.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OPU51_RS01690 (OPU51_01690) 368902..369201 + 300 WP_008806992.1 XRE family transcriptional regulator Antitoxin
OPU51_RS01695 (OPU51_01695) 369264..370772 - 1509 WP_032740278.1 glycerol-3-phosphate dehydrogenase -
OPU51_RS01700 (OPU51_01700) 370977..371306 + 330 WP_004202138.1 thiosulfate sulfurtransferase GlpE -
OPU51_RS01705 (OPU51_01705) 371357..372187 + 831 WP_008806994.1 rhomboid family intramembrane serine protease GlpG -
OPU51_RS01710 (OPU51_01710) 372237..372995 + 759 WP_008806995.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13474.43 Da        Isoelectric Point: 6.2327

>T266592 WP_032731351.1 NZ_CP114354:368555-368902 [Klebsiella variicola]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFGPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKETITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10814.61 Da        Isoelectric Point: 10.1464

>AT266592 WP_008806992.1 NZ_CP114354:368902-369201 [Klebsiella variicola]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2V3KK24

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2LZT5

References