Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4164633..4165230 Replicon chromosome
Accession NZ_CP114332
Organism Klebsiella variicola strain 2022CK-00505

Toxin (Protein)


Gene name higB Uniprot ID A0A0B7GEF2
Locus tag OGU18_RS20285 Protein ID WP_012542526.1
Coordinates 4164913..4165230 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OGU18_RS20280 Protein ID WP_012542525.1
Coordinates 4164633..4164920 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGU18_RS20250 (OGU18_20245) 4160537..4160785 + 249 WP_008805539.1 DUF1158 domain-containing protein -
OGU18_RS20255 (OGU18_20250) 4160802..4161143 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
OGU18_RS20260 (OGU18_20255) 4161174..4162289 - 1116 WP_162823038.1 MBL fold metallo-hydrolase -
OGU18_RS20265 (OGU18_20260) 4162469..4163050 + 582 WP_012968754.1 TetR/AcrR family transcriptional regulator -
OGU18_RS20270 (OGU18_20265) 4163050..4163418 + 369 WP_008805536.1 MmcQ/YjbR family DNA-binding protein -
OGU18_RS20275 (OGU18_20270) 4163538..4164191 + 654 WP_032729541.1 oxygen-insensitive NAD(P)H nitroreductase -
OGU18_RS20280 (OGU18_20275) 4164633..4164920 - 288 WP_012542525.1 helix-turn-helix transcriptional regulator Antitoxin
OGU18_RS20285 (OGU18_20280) 4164913..4165230 - 318 WP_012542526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OGU18_RS20290 (OGU18_20285) 4165415..4166458 - 1044 WP_269136554.1 DUF2157 domain-containing protein -
OGU18_RS20295 (OGU18_20290) 4166923..4167789 - 867 WP_008805530.1 helix-turn-helix transcriptional regulator -
OGU18_RS20300 (OGU18_20295) 4167898..4169325 + 1428 WP_023297179.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-89)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12092.35 Da        Isoelectric Point: 11.2767

>T266583 WP_012542526.1 NZ_CP114332:c4165230-4164913 [Klebsiella variicola]
IFRLVVHVDVKKELQALPPIVQAKMIRQIDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10815.51 Da        Isoelectric Point: 10.2212

>AT266583 WP_012542525.1 NZ_CP114332:c4164920-4164633 [Klebsiella variicola]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQILLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7GEF2

Antitoxin

Source ID Structure

References