Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 800198..800721 Replicon chromosome
Accession NC_017342
Organism Staphylococcus aureus subsp. aureus TCH60

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2W3LFI1
Locus tag HMPREF0772_RS03820 Protein ID WP_000074047.1
Coordinates 800455..800721 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag HMPREF0772_RS03815 Protein ID WP_000587617.1
Coordinates 800198..800455 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HMPREF0772_RS03790 795276..796469 + 1194 WP_000675407.1 MFS transporter -
HMPREF0772_RS03795 796693..797442 - 750 WP_000072447.1 CPBP family intramembrane metalloprotease -
HMPREF0772_RS03800 797638..799215 + 1578 WP_000143489.1 FMN-binding glutamate synthase family protein -
HMPREF0772_RS03805 799383..799838 - 456 WP_000732090.1 YehR family lipoprotein -
HMPREF0772_RS03815 800198..800455 + 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HMPREF0772_RS03820 800455..800721 + 267 WP_000074047.1 Txe/YoeB family addiction module toxin Toxin
HMPREF0772_RS03825 801077..802153 + 1077 WP_001076679.1 M42 family metallopeptidase -
HMPREF0772_RS03830 802499..803161 + 663 WP_000923514.1 ATP-binding cassette domain-containing protein -
HMPREF0772_RS03835 803154..803930 + 777 WP_000072154.1 iron export ABC transporter permease subunit FetB -
HMPREF0772_RS03840 804324..805511 + 1188 WP_000026190.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10662.26 Da        Isoelectric Point: 10.1384

>T26657 WP_000074047.1 NC_017342:800455-800721 [Staphylococcus aureus subsp. aureus TCH60]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRIVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T26657 NC_017342:800455-800721 [Staphylococcus aureus subsp. aureus TCH60]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGATCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT26657 WP_000587617.1 NC_017342:800198-800455 [Staphylococcus aureus subsp. aureus TCH60]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT26657 NC_017342:800198-800455 [Staphylococcus aureus subsp. aureus TCH60]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W3LFI1

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References