Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4164242..4164839 Replicon chromosome
Accession NZ_CP114324
Organism Klebsiella variicola strain 2022CK-00503

Toxin (Protein)


Gene name higB Uniprot ID A0A0B7GEF2
Locus tag OEE48_RS20270 Protein ID WP_012542526.1
Coordinates 4164522..4164839 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OEE48_RS20265 Protein ID WP_012542525.1
Coordinates 4164242..4164529 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEE48_RS20235 (OEE48_20230) 4160146..4160394 + 249 WP_008805539.1 DUF1158 domain-containing protein -
OEE48_RS20240 (OEE48_20235) 4160411..4160752 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
OEE48_RS20245 (OEE48_20240) 4160783..4161898 - 1116 WP_162823038.1 MBL fold metallo-hydrolase -
OEE48_RS20250 (OEE48_20245) 4162078..4162659 + 582 WP_012968754.1 TetR/AcrR family transcriptional regulator -
OEE48_RS20255 (OEE48_20250) 4162659..4163027 + 369 WP_008805536.1 MmcQ/YjbR family DNA-binding protein -
OEE48_RS20260 (OEE48_20255) 4163147..4163800 + 654 WP_032729541.1 oxygen-insensitive NAD(P)H nitroreductase -
OEE48_RS20265 (OEE48_20260) 4164242..4164529 - 288 WP_012542525.1 helix-turn-helix transcriptional regulator Antitoxin
OEE48_RS20270 (OEE48_20265) 4164522..4164839 - 318 WP_012542526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OEE48_RS20275 (OEE48_20270) 4165024..4166067 - 1044 WP_269136554.1 DUF2157 domain-containing protein -
OEE48_RS20280 (OEE48_20275) 4166532..4167398 - 867 WP_008805530.1 helix-turn-helix transcriptional regulator -
OEE48_RS20285 (OEE48_20280) 4167507..4168934 + 1428 WP_023297179.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-89)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12092.35 Da        Isoelectric Point: 11.2767

>T266545 WP_012542526.1 NZ_CP114324:c4164839-4164522 [Klebsiella variicola]
IFRLVVHVDVKKELQALPPIVQAKMIRQIDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10815.51 Da        Isoelectric Point: 10.2212

>AT266545 WP_012542525.1 NZ_CP114324:c4164529-4164242 [Klebsiella variicola]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQILLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7GEF2

Antitoxin

Source ID Structure

References