Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 44465..45115 Replicon chromosome
Accession NZ_CP114308
Organism Klebsiella oxytoca strain 2022CK-00499

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag OEE41_RS00210 Protein ID WP_017145202.1
Coordinates 44465..44806 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OEE41_RS00215 Protein ID WP_017145203.1
Coordinates 44816..45115 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEE41_RS00195 (OEE41_00195) 40727..42046 + 1320 WP_004107101.1 MFS transporter -
OEE41_RS00200 (OEE41_00200) 42192..43583 + 1392 WP_004107098.1 hexose-6-phosphate:phosphate antiporter -
OEE41_RS00205 (OEE41_00205) 43761..44213 + 453 WP_064355354.1 DUF1198 domain-containing protein -
OEE41_RS00210 (OEE41_00210) 44465..44806 + 342 WP_017145202.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OEE41_RS00215 (OEE41_00215) 44816..45115 + 300 WP_017145203.1 helix-turn-helix transcriptional regulator Antitoxin
OEE41_RS00220 (OEE41_00220) 45234..46415 + 1182 WP_017145204.1 purine ribonucleoside efflux pump NepI -
OEE41_RS00225 (OEE41_00225) 46447..47256 - 810 WP_017145205.1 phosphonoacetaldehyde hydrolase -
OEE41_RS00230 (OEE41_00230) 47266..48369 - 1104 WP_017145206.1 2-aminoethylphosphonate--pyruvate transaminase -
OEE41_RS00235 (OEE41_00235) 48510..49229 + 720 WP_070556485.1 phosphonate utilization transcriptional regulator PhnR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(8-88)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13011.85 Da        Isoelectric Point: 5.1871

>T266467 WP_017145202.1 NZ_CP114308:44465-44806 [Klebsiella oxytoca]
MWNVETTEVFDKWFEAQTEALKEDMLAAMVILSEYGPQLGRPFADTVNDSAFSNMKELRVQHQGSPIRAFFVFDPSRCGI
LLCAGDKTGLNEKRFYKDMIKLADAEYRKHLNQ

Download         Length: 342 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10874.80 Da        Isoelectric Point: 10.0948

>AT266467 WP_017145203.1 NZ_CP114308:44816-45115 [Klebsiella oxytoca]
MATLKELMAKQSPESQARIAEKVEAMRQVIALSMLREELNLSQAELAKAMGVKQPTIAKMEQADNDPRLSTLKRYVAALG
GELSIDVKLPGGKRIAFHL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References