266453

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 3582349..3583582 Replicon chromosome
Accession NZ_CP114289
Organism Flavobacterium limnophilum strain IMCC36791

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag OZP13_RS14870 Protein ID WP_269240899.1
Coordinates 3582349..3583272 (-) Length 308 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag OZP13_RS14875 Protein ID WP_281297675.1
Coordinates 3583265..3583582 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OZP13_RS14845 3577750..3578622 + 873 WP_269240893.1 AraC family transcriptional regulator -
OZP13_RS14850 3578761..3579375 - 615 WP_281297674.1 hypothetical protein -
OZP13_RS14855 3579805..3580521 + 717 WP_269240896.1 DsbA family oxidoreductase -
OZP13_RS14860 3580647..3581921 + 1275 WP_269240897.1 Y-family DNA polymerase -
OZP13_RS14865 3581912..3582352 + 441 WP_269240898.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
OZP13_RS14870 3582349..3583272 - 924 WP_269240899.1 HipA domain-containing protein Toxin
OZP13_RS14875 3583265..3583582 - 318 WP_281297675.1 HipA N-terminal domain-containing protein Antitoxin
OZP13_RS14880 3583582..3583791 - 210 WP_269240902.1 helix-turn-helix domain-containing protein -
OZP13_RS14885 3584248..3584580 + 333 WP_269240904.1 type II toxin-antitoxin system RelE/ParE family toxin -
OZP13_RS14890 3584568..3584888 + 321 WP_269240905.1 helix-turn-helix transcriptional regulator -
OZP13_RS14895 3585032..3585442 + 411 WP_281297676.1 hypothetical protein -
OZP13_RS14905 3585963..3586904 + 942 WP_281297677.1 ribose-phosphate pyrophosphokinase -
OZP13_RS14910 3586973..3587581 + 609 WP_269240908.1 50S ribosomal protein L25/general stress protein Ctc -
OZP13_RS14915 3587713..3588387 + 675 WP_281297678.1 aminoacyl-tRNA hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(52-279)

Antitoxin

HipA, N-terminal subdomain 1

(6-99)


Sequences

Toxin        


Download         Length: 308 a.a.        Molecular weight: 35284.77 Da        Isoelectric Point: 8.8824

>T266453 WP_269240899.1 NZ_CP114289:c3583272-3582349 [Flavobacterium limnophilum]
MNRCPITYELCGTEKYSEKGLRLIAPKLTALNDLPFTAAEQRQEAANRANKLSIQGVQPKLSAVISVVKQQFEIVDQFGN
YIIKPQNDIFLELPENEDVTMKMAKVYGLEVPFHGLVYSKDGSLSYFIKRFDRYSKGKKYATEDFAQLSGNSRDTKYDYT
MEKLVKVIDEFCTFPAIAKADFFKRVLFCFITGNEDMHLKNFSVITKAGKTTLAPVYDFLNSSISIKNPQEELALSLKGK
KSNFKSTELIDYYAKERLELNDKTIDVILSDMNKSVSKWTELVEISFLSDVMKEKYLKLMENRIKRF

Download         Length: 924 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11782.49 Da        Isoelectric Point: 4.6533

>AT266453 WP_281297675.1 NZ_CP114289:c3583582-3583265 [Flavobacterium limnophilum]
MMRKATILVHDKRAGILMEDNAGGYQFTYDDNYEGEPVSLTMPLTAKHYSFAKFPSFFEGLLPEGIMLEGLLKIGKIDKN
DYFSQLVATGNDLVGAVTVKEWKDE

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References