Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 149893..150553 Replicon chromosome
Accession NZ_CP114281
Organism Gallibacterium anatis strain ESV200

Toxin (Protein)


Gene name higB Uniprot ID A0A0A3A103
Locus tag CF557_RS00830 Protein ID WP_052124504.1
Coordinates 150194..150553 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0A2ZWF9
Locus tag CF557_RS00825 Protein ID WP_039163779.1
Coordinates 149893..150192 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CF557_RS00800 (CF557_00800) 145161..146234 + 1074 WP_094873102.1 DUF3383 family protein -
CF557_RS00805 (CF557_00805) 146286..146711 + 426 WP_039163784.1 DUF3277 family protein -
CF557_RS00810 (CF557_00810) 146711..147196 + 486 WP_094873099.1 hypothetical protein -
CF557_RS00815 (CF557_00815) 147232..147384 + 153 WP_017805951.1 hypothetical protein -
CF557_RS00820 (CF557_00820) 147381..149855 + 2475 WP_094873096.1 tape measure protein -
CF557_RS00825 (CF557_00825) 149893..150192 - 300 WP_039163779.1 helix-turn-helix transcriptional regulator Antitoxin
CF557_RS00830 (CF557_00830) 150194..150553 - 360 WP_052124504.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CF557_RS00835 (CF557_00835) 150619..151197 + 579 WP_094873093.1 hypothetical protein -
CF557_RS00840 (CF557_00840) 151197..151529 + 333 WP_017805944.1 hypothetical protein -
CF557_RS00845 (CF557_00845) 151507..152472 + 966 WP_094873090.1 hypothetical protein -
CF557_RS00850 (CF557_00850) 152465..153136 + 672 WP_094873088.1 Gp138 family membrane-puncturing spike protein -
CF557_RS00855 (CF557_00855) 153133..153498 + 366 WP_017805941.1 hypothetical protein -
CF557_RS00860 (CF557_00860) 153491..154927 + 1437 WP_094873085.1 baseplate J/gp47 family protein -
CF557_RS00865 (CF557_00865) 154936..155550 + 615 WP_094873082.1 DUF2612 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 112587..158897 46310


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(17-110)

Antitoxin

HigA2-like, helix-turn-helix domain

(8-87)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13592.72 Da        Isoelectric Point: 9.4530

>T266445 WP_052124504.1 NZ_CP114281:c150553-150194 [Gallibacterium anatis]
MAVNHQWNILFTDCFSKWLDQQDIPTKKSVAAALNLLKITGPELSRPYADTIKGSQYPNMKELRIQHQGKPLRAFFAFDP
LRQAIVLCAGDKSNDKQFYKRMIALADTEFAAYLANLEK

Download         Length: 360 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11321.03 Da        Isoelectric Point: 4.4463

>AT266445 WP_039163779.1 NZ_CP114281:c150192-149893 [Gallibacterium anatis]
MKTFDQFLDEFSPEDRKDIERMTDELLLESGLSLIRQEMEISQKQLADALGISQPAVAQIEQRGNDLRLSTLKRYVETMG
GKLSLAIDMPMGETRIFKI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A3A103

Antitoxin

Source ID Structure
AlphaFold DB A0A0A2ZWF9

References