Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 3571584..3572278 Replicon chromosome
Accession NZ_CP114280
Organism Dickeya lacustris strain LMG30899

Toxin (Protein)


Gene name yafO Uniprot ID E0SCS6
Locus tag O1Q98_RS16115 Protein ID WP_013319142.1
Coordinates 3571874..3572278 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID -
Locus tag O1Q98_RS16110 Protein ID WP_125259776.1
Coordinates 3571584..3571877 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O1Q98_RS16090 (O1Q98_16095) 3567225..3567554 + 330 WP_015854059.1 HGGxSTG domain-containing protein -
O1Q98_RS16095 (O1Q98_16100) 3567944..3568978 + 1035 WP_125259773.1 hypothetical protein -
O1Q98_RS16100 (O1Q98_16105) 3568978..3570003 + 1026 WP_125259774.1 DUF262 domain-containing protein -
O1Q98_RS16105 (O1Q98_16110) 3570859..3571476 + 618 WP_125259775.1 hypothetical protein -
O1Q98_RS16110 (O1Q98_16115) 3571584..3571877 + 294 WP_125259776.1 type I toxin-antitoxin system antitoxin YafN Antitoxin
O1Q98_RS16115 (O1Q98_16120) 3571874..3572278 + 405 WP_013319142.1 type II toxin-antitoxin system YafO family toxin Toxin
O1Q98_RS16125 (O1Q98_16130) 3573903..3574976 + 1074 WP_125260204.1 hypothetical protein -
O1Q98_RS16130 (O1Q98_16135) 3575820..3576056 + 237 WP_038923672.1 AlpA family phage regulatory protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3561656..3600343 38687
- flank IS/Tn - - 3573183..3573521 338


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(29-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15477.77 Da        Isoelectric Point: 7.0609

>T266442 WP_013319142.1 NZ_CP114280:3571874-3572278 [Dickeya lacustris]
MSIRIFKSTLIRQQLSPQELDDLVADFLSYKKEGVLPDTFGRDAPYDDDRTYPLVKEEQVAHIHLADADAPFPKFLRQFK
RTSDQAHLVYCQGASDPDAYLLIIILKPEAHKMARNNNHMHKIGVMAEAFRMKY

Download         Length: 405 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10976.44 Da        Isoelectric Point: 4.9062

>AT266442 WP_125259776.1 NZ_CP114280:3571584-3571877 [Dickeya lacustris]
MERILAEKSINITELRKNPAKYFIDEPVAVLSNNRPAGYMVSAKVFEELIDLLEEKQGRVHTAARFRPGAERLSEIAQNG
QTLLQNASDKDLTEFTE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E0SCS6

Antitoxin

Source ID Structure

References