Detailed information of TA system TA026643

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2119897..2120196
• Replicon: chromosome
• Accession: NC_017341
• Organism: Staphylococcus aureus subsp. aureus str. JKD6008

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A4U0AGH1
• Locus tag: SAA6008_RS15775
• Protein ID: WP_072482930.1
• Coordinates: 2120020..2120196 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2119897..2119952 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAA6008_RS10760	2116420..2116986	+	567	WP_001807342.1	multidrug-binding transcriptional regulator QacR	-
SAA6008_RS10765	2117119..2117304	-	186	WP_000797248.1	helix-turn-helix transcriptional regulator	-
SAA6008_RS10770	2117309..2117647	-	339	WP_001049146.1	hypothetical protein	-
SAA6008_RS10775	2117893..2118501	-	609	WP_000583528.1	recombinase family protein	-
SAA6008_RS10780	2118784..2119047	+	264	WP_000495112.1	DUF4238 domain-containing protein	-
SAA6008_RS10785	2119077..2119751	+	675	WP_001106019.1	IS6-like element IS257 family transposase	-
SAA6008_RS10790	2119860..2119967	+	108	Protein_2053	hypothetical protein	-
-	2119889..2120028	+	140	NuclAT_0	-	-
-	2119889..2120028	+	140	NuclAT_0	-	-
-	2119889..2120028	+	140	NuclAT_0	-	-
-	2119889..2120028	+	140	NuclAT_0	-	-
-	2119897..2119952	+	56	-	-	Antitoxin
SAA6008_RS15775	2120020..2120196	-	177	WP_072482930.1	putative holin-like toxin	Toxin
SAA6008_RS10800	2120305..2121078	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
SAA6008_RS10805	2121451..2121825	-	375	WP_000340977.1	hypothetical protein	-
SAA6008_RS10810	2121881..2122168	-	288	WP_001262621.1	hypothetical protein	-
SAA6008_RS10815	2122214..2122366	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sea / hlb / groEL	2117119..2175154	58035

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6883.46 Da
• Isoelectric Point: 10.6777

>T26643 WP_072482930.1 NC_017341:c2120196-2120020 [Staphylococcus aureus subsp. aureus str. JKD6008]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIAFIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T26643 NC_017341:c2120196-2120020 [Staphylococcus aureus subsp. aureus str. JKD6008]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTCATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT26643 NC_017341:2119897-2119952 [Staphylococcus aureus subsp. aureus str. JKD6008]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A4U0AGH1

Antitoxin