Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3313298..3313891 Replicon chromosome
Accession NZ_CP114201
Organism Delftia acidovorans strain BIM B-1761

Toxin (Protein)


Gene name higB Uniprot ID F6ASE3
Locus tag O1V13_RS14965 Protein ID WP_013802475.1
Coordinates 3313613..3313891 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag O1V13_RS14960 Protein ID WP_043791964.1
Coordinates 3313298..3313600 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O1V13_RS14940 (O1V13_14940) 3308635..3309486 + 852 WP_269199085.1 YggS family pyridoxal phosphate-dependent enzyme -
O1V13_RS14945 (O1V13_14945) 3309544..3310782 + 1239 WP_269199086.1 aspartate aminotransferase family protein -
O1V13_RS14950 (O1V13_14950) 3310829..3312103 + 1275 WP_043821928.1 serine hydroxymethyltransferase -
O1V13_RS14955 (O1V13_14955) 3312125..3313183 - 1059 WP_269199087.1 patatin-like phospholipase family protein -
O1V13_RS14960 (O1V13_14960) 3313298..3313600 - 303 WP_043791964.1 HigA family addiction module antitoxin Antitoxin
O1V13_RS14965 (O1V13_14965) 3313613..3313891 - 279 WP_013802475.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O1V13_RS14970 (O1V13_14970) 3313958..3314860 - 903 WP_013802476.1 LysR family transcriptional regulator -
O1V13_RS14975 (O1V13_14975) 3314875..3315411 - 537 WP_012205532.1 MarR family winged helix-turn-helix transcriptional regulator -
O1V13_RS14980 (O1V13_14980) 3315616..3316824 + 1209 WP_269199088.1 3-hydroxybenzoate 6-monooxygenase -
O1V13_RS14985 (O1V13_14985) 3316841..3317878 + 1038 WP_269199089.1 cupin domain-containing protein -
O1V13_RS14990 (O1V13_14990) 3317917..3318624 + 708 WP_269199090.1 fumarylacetoacetate hydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10518.17 Da        Isoelectric Point: 9.2618

>T266423 WP_013802475.1 NZ_CP114201:c3313891-3313613 [Delftia acidovorans]
MILDFRCADTQALMLGKRVARFANLEAAAMRKLVQLNAATSLEFLRIPPGNRLEALQGSRRGQYSIRINEQWRLCFVWAD
GHASQVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11378.09 Da        Isoelectric Point: 5.1007

>AT266423 WP_043791964.1 NZ_CP114201:c3313600-3313298 [Delftia acidovorans]
MTREVKWPHPGEILMQEWLEPMGLSQYALAKAIDVPPRRINEIVKGMRGITADTALRLAVFFGTDAQSWLNLQSDYDLAE
ARDAMADVLARIQRFEPTHP

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A031I1T8

Antitoxin

Source ID Structure

References