Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 348997..349672 Replicon chromosome
Accession NZ_CP114201
Organism Delftia acidovorans strain BIM B-1761

Toxin (Protein)


Gene name higB Uniprot ID F6AKY9
Locus tag O1V13_RS01540 Protein ID WP_013800178.1
Coordinates 348997..349380 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID F6AKZ0
Locus tag O1V13_RS01545 Protein ID WP_013800179.1
Coordinates 349361..349672 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O1V13_RS01525 (O1V13_01525) 346301..347032 + 732 WP_013800176.1 TorF family putative porin -
O1V13_RS01530 (O1V13_01530) 347056..347394 + 339 WP_012202241.1 P-II family nitrogen regulator -
O1V13_RS01535 (O1V13_01535) 347426..348799 + 1374 WP_170962109.1 ammonium transporter -
O1V13_RS01540 (O1V13_01540) 348997..349380 + 384 WP_013800178.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O1V13_RS01545 (O1V13_01545) 349361..349672 + 312 WP_013800179.1 helix-turn-helix transcriptional regulator Antitoxin
O1V13_RS01550 (O1V13_01550) 349809..350963 + 1155 WP_269197960.1 glycolate oxidase subunit GlcE -
O1V13_RS01555 (O1V13_01555) 350989..351771 + 783 WP_012202244.1 YoaK family protein -
O1V13_RS01560 (O1V13_01560) 351833..353083 + 1251 WP_269197961.1 glycolate oxidase subunit GlcF -
O1V13_RS01565 (O1V13_01565) 353168..354034 + 867 WP_034397802.1 ProQ/FinO family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14752.44 Da        Isoelectric Point: 5.2260

>T266420 WP_013800178.1 NZ_CP114201:348997-349380 [Delftia acidovorans]
MTQPWEVEYTDELGDWWADLTQAEQESIDASVRLLEARGPNLGYPHTSGIGRSRHPHMRELRVQHEGRPYRLLYAFDPRR
CAILLIGGDKTGDGRWYEVHVPIADRLYDTHLETLQKEGRIDGQEIQ

Download         Length: 384 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11803.60 Da        Isoelectric Point: 9.8220

>AT266420 WP_013800179.1 NZ_CP114201:349361-349672 [Delftia acidovorans]
MARKFSELRARMSPEAQSRAAARAEAMLVEMQLQELRKARNVTQVEVARAMNVEQASISKLERREDMYVSTLREYVRALG
GELRLVASFPDADIQVHPFEPLR

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A031HZS7

Antitoxin

Source ID Structure
AlphaFold DB A0A031I0J9

References