Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 225578..226175 Replicon chromosome
Accession NZ_CP114168
Organism Klebsiella variicola strain 2022CK-00565

Toxin (Protein)


Gene name higB Uniprot ID A0A0B7GEF2
Locus tag OIX89_RS01090 Protein ID WP_012542526.1
Coordinates 225858..226175 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OIX89_RS01085 Protein ID WP_012542525.1
Coordinates 225578..225865 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIX89_RS01055 (OIX89_01055) 221482..221730 + 249 WP_008805539.1 DUF1158 domain-containing protein -
OIX89_RS01060 (OIX89_01060) 221747..222088 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
OIX89_RS01065 (OIX89_01065) 222119..223234 - 1116 WP_162823038.1 MBL fold metallo-hydrolase -
OIX89_RS01070 (OIX89_01070) 223414..223995 + 582 WP_012968754.1 TetR/AcrR family transcriptional regulator -
OIX89_RS01075 (OIX89_01075) 223995..224363 + 369 WP_008805536.1 MmcQ/YjbR family DNA-binding protein -
OIX89_RS01080 (OIX89_01080) 224483..225136 + 654 WP_032729541.1 oxygen-insensitive NAD(P)H nitroreductase -
OIX89_RS01085 (OIX89_01085) 225578..225865 - 288 WP_012542525.1 helix-turn-helix transcriptional regulator Antitoxin
OIX89_RS01090 (OIX89_01090) 225858..226175 - 318 WP_012542526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OIX89_RS01095 (OIX89_01095) 226360..227403 - 1044 WP_269136554.1 DUF2157 domain-containing protein -
OIX89_RS01100 (OIX89_01100) 227868..228734 - 867 WP_008805530.1 helix-turn-helix transcriptional regulator -
OIX89_RS01105 (OIX89_01105) 228843..230270 + 1428 WP_023297179.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-89)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12092.35 Da        Isoelectric Point: 11.2767

>T266387 WP_012542526.1 NZ_CP114168:c226175-225858 [Klebsiella variicola]
IFRLVVHVDVKKELQALPPIVQAKMIRQIDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10815.51 Da        Isoelectric Point: 10.2212

>AT266387 WP_012542525.1 NZ_CP114168:c225865-225578 [Klebsiella variicola]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQILLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7GEF2

Antitoxin

Source ID Structure

References