Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1788987..1789647 Replicon chromosome
Accession NZ_CP114160
Organism Klebsiella quasipneumoniae strain 2022CK-00516

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N5B28_RS08660 Protein ID WP_072413417.1
Coordinates 1789294..1789647 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N5B28_RS08655 Protein ID WP_072413418.1
Coordinates 1788987..1789289 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5B28_RS08630 (1784193) 1784193..1785296 - 1104 WP_130953023.1 AarF/UbiB family protein -
N5B28_RS08640 (1785819) 1785819..1787255 + 1437 WP_032456343.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
N5B28_RS08650 (1787619) 1787619..1788551 + 933 Protein_1687 integrase arm-type DNA-binding domain-containing protein -
N5B28_RS08655 (1788987) 1788987..1789289 - 303 WP_072413418.1 XRE family transcriptional regulator Antitoxin
N5B28_RS08660 (1789294) 1789294..1789647 - 354 WP_072413417.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5B28_RS08665 (1790145) 1790145..1790366 - 222 WP_047738806.1 helix-turn-helix transcriptional regulator -
N5B28_RS08670 (1790363) 1790363..1790824 - 462 WP_049004530.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13500.41 Da        Isoelectric Point: 9.5699

>T266356 WP_072413417.1 NZ_CP114160:c1789647-1789294 [Klebsiella quasipneumoniae]
MWTIKTTDTFDRWFASLSDTDRVSMLAALLVLREKGPGLSRPYADTVRGSRYSNMKELRIQSRGDPIRAFFAFDPTRTGI
VLCAGNKVGNEKRFYDEMLPVADREFTNWLNTLKEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10998.71 Da        Isoelectric Point: 5.7316

>AT266356 WP_072413418.1 NZ_CP114160:c1789289-1788987 [Klebsiella quasipneumoniae]
VGRTLEQLIADEKSEVVAEAQAMATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References