Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2479226..2479743 | Replicon | chromosome |
| Accession | NC_017340 | ||
| Organism | Staphylococcus aureus 04-02981 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
| Locus tag | SA2981_RS12625 | Protein ID | WP_000113265.1 |
| Coordinates | 2479226..2479492 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | SA2981_RS12630 | Protein ID | WP_000584499.1 |
| Coordinates | 2479492..2479743 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SA2981_RS12600 | 2474654..2475190 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| SA2981_RS12605 | 2475424..2476248 | - | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
| SA2981_RS12610 | 2476465..2476647 | - | 183 | WP_000230292.1 | hypothetical protein | - |
| SA2981_RS12615 | 2476731..2477198 | - | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
| SA2981_RS12620 | 2477384..2478931 | - | 1548 | WP_000727772.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| SA2981_RS14885 | 2479120..2479191 | - | 72 | Protein_2390 | hypothetical protein | - |
| SA2981_RS12625 | 2479226..2479492 | - | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
| SA2981_RS12630 | 2479492..2479743 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| SA2981_RS12635 | 2479908..2480009 | - | 102 | Protein_2393 | hypothetical protein | - |
| SA2981_RS12640 | 2480016..2480615 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| SA2981_RS12645 | 2480634..2480996 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| SA2981_RS12650 | 2481251..2482501 | + | 1251 | WP_001012225.1 | FemA/FemB family glycyltransferase FmhA | - |
| SA2981_RS12655 | 2482598..2483329 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| SA2981_RS12660 | 2483326..2484045 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T26634 WP_000113265.1 NC_017340:c2479492-2479226 [Staphylococcus aureus 04-02981]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T26634 NC_017340:c2479492-2479226 [Staphylococcus aureus 04-02981]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT26634 WP_000584499.1 NC_017340:c2479743-2479492 [Staphylococcus aureus 04-02981]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT26634 NC_017340:c2479743-2479492 [Staphylococcus aureus 04-02981]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|