Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4069005..4069595 Replicon chromosome
Accession NZ_CP114134
Organism Xanthomonas fragariae strain YLX21

Toxin (Protein)


Gene name graT Uniprot ID A0A2N7V9W3
Locus tag OZ429_RS19275 Protein ID WP_016902142.1
Coordinates 4069314..4069595 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID A0A1A9MEX2
Locus tag OZ429_RS19270 Protein ID WP_064507888.1
Coordinates 4069005..4069295 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OZ429_RS19240 (OZ429_19240) 4064472..4065113 + 642 WP_269123908.1 restriction endonuclease -
OZ429_RS19245 (OZ429_19245) 4065229..4066185 + 957 WP_269123910.1 IS30 family transposase -
OZ429_RS19250 (OZ429_19250) 4066197..4067102 - 906 WP_269123912.1 hypothetical protein -
OZ429_RS19255 (OZ429_19255) 4067165..4067692 - 528 WP_269123914.1 hypothetical protein -
OZ429_RS19260 (OZ429_19260) 4068132..4068464 + 333 WP_208588210.1 hypothetical protein -
OZ429_RS19265 (OZ429_19265) 4068624..4068814 + 191 Protein_3618 hypothetical protein -
OZ429_RS19270 (OZ429_19270) 4069005..4069295 - 291 WP_064507888.1 HigA family addiction module antitoxin Antitoxin
OZ429_RS19275 (OZ429_19275) 4069314..4069595 - 282 WP_016902142.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OZ429_RS19280 (OZ429_19280) 4070057..4072192 - 2136 WP_269123922.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4065229..4066185 956


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-94)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11064.75 Da        Isoelectric Point: 9.7972

>T266326 WP_016902142.1 NZ_CP114134:c4069595-4069314 [Xanthomonas fragariae]
MIRSFVDKEAEKIWMGERSRRLPADIQSVARRKLRMLNAAAHLDDLRIPPANRLEALKGERRGQYSIRINDQWRICFRWM
EGDVAEVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10482.16 Da        Isoelectric Point: 7.2043

>AT266326 WP_064507888.1 NZ_CP114134:c4069295-4069005 [Xanthomonas fragariae]
MTVLPNIHPGEILLEEFLEPMGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTTERFWLGLQADYELEQA
HRALGDLPSRIKRLAA

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N7V9W3

Antitoxin

Source ID Structure
AlphaFold DB A0A1A9MEX2

References