Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4368148..4368560 Replicon chromosome
Accession NZ_CP114130
Organism Escherichia coli strain NJS001

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag N0F11_RS21875 Protein ID WP_000132630.1
Coordinates 4368219..4368560 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4368148..4368224 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0F11_RS21865 (4364775) 4364775..4366244 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
N0F11_RS21870 (4366244) 4366244..4367998 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- (4368148) 4368148..4368224 - 77 NuclAT_12 - Antitoxin
- (4368148) 4368148..4368224 - 77 NuclAT_12 - Antitoxin
- (4368148) 4368148..4368224 - 77 NuclAT_12 - Antitoxin
- (4368148) 4368148..4368224 - 77 NuclAT_12 - Antitoxin
- (4368148) 4368148..4368224 - 77 NuclAT_13 - Antitoxin
- (4368148) 4368148..4368224 - 77 NuclAT_13 - Antitoxin
- (4368148) 4368148..4368224 - 77 NuclAT_13 - Antitoxin
- (4368148) 4368148..4368224 - 77 NuclAT_13 - Antitoxin
N0F11_RS21875 (4368219) 4368219..4368560 + 342 WP_000132630.1 endoribonuclease SymE Toxin
N0F11_RS21880 (4368607) 4368607..4369770 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
N0F11_RS21885 (4369818) 4369818..4370699 - 882 WP_001304007.1 DUF262 domain-containing protein -
N0F11_RS21890 (4370842) 4370842..4370994 - 153 WP_001418365.1 hypothetical protein -
N0F11_RS21895 (4371137) 4371137..4372549 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4360347..4381580 21233


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T266312 WP_000132630.1 NZ_CP114130:4368219-4368560 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT266312 NZ_CP114130:c4368224-4368148 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References