Detailed information of TA system TA266306

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3099890..3100115
• Replicon: chromosome
• Accession: NZ_CP114130
• Organism: Escherichia coli strain NJS001

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: N0F11_RS15905
• Protein ID: WP_000813263.1
• Coordinates: 3099890..3100045 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	3100057..3100115 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
N0F11_RS15870	3095344..3096057	-	714	WP_000261909.1	helix-turn-helix domain-containing protein	-
N0F11_RS15875	3096195..3096391	-	197	Protein_3114	TrmB family transcriptional regulator	-
N0F11_RS15880	3096678..3097496	-	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
N0F11_RS15885	3097648..3098019	-	372	WP_000090264.1	antiterminator Q family protein	-
N0F11_RS15890	3098009..3098380	-	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
N0F11_RS15895	3098393..3099442	-	1050	WP_021497113.1	DUF968 domain-containing protein	-
N0F11_RS15900	3099444..3099722	-	279	WP_001341388.1	hypothetical protein	-
N0F11_RS15905	3099890..3100045	-	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
-	3100057..3100115	+	59	-	-	Antitoxin
N0F11_RS15910	3100650..3101423	+	774	WP_000160654.1	alpha/beta hydrolase	-
N0F11_RS15915	3101775..3102188	-	414	WP_001151233.1	DUF977 family protein	-
N0F11_RS15920	3102204..3102974	-	771	WP_000450992.1	DUF1627 domain-containing protein	-
N0F11_RS15925	3102996..3103742	-	747	WP_000788751.1	ATP-binding protein	-
N0F11_RS15930	3103749..3104840	-	1092	WP_001205823.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T266306 WP_000813263.1 NZ_CP114130:c3100045-3099890 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

Antitoxin

Nucleotide

• Length: 59 bp

>AT266306 NZ_CP114130:3100057-3100115 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin