Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3960186..3960727 Replicon chromosome
Accession NZ_CP114128
Organism Escherichia coli strain PE164

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag LZG51_RS19400 Protein ID WP_096220693.1
Coordinates 3960449..3960727 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag LZG51_RS19395 Protein ID WP_000729704.1
Coordinates 3960186..3960446 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZG51_RS19370 (3955969) 3955969..3956754 - 786 WP_000207551.1 putative lateral flagellar export/assembly protein LafU -
LZG51_RS19375 (3956726) 3956726..3958438 + 1713 Protein_3794 flagellar biosynthesis protein FlhA -
LZG51_RS19380 (3958543) 3958543..3958821 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
LZG51_RS19385 (3958814) 3958814..3959170 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
LZG51_RS19390 (3959227) 3959227..3959976 - 750 WP_053884036.1 C40 family peptidase -
LZG51_RS19395 (3960186) 3960186..3960446 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
LZG51_RS19400 (3960449) 3960449..3960727 + 279 WP_096220693.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
LZG51_RS19405 (3960883) 3960883..3961623 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
LZG51_RS19410 (3961594) 3961594..3962361 - 768 WP_000333380.1 class II glutamine amidotransferase -
LZG51_RS19415 (3962567) 3962567..3963145 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10844.60 Da        Isoelectric Point: 9.9107

>T266283 WP_096220693.1 NZ_CP114128:3960449-3960727 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHNDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWLLIYKLTDKLLR
FERTGTHAVLFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT266283 WP_000729704.1 NZ_CP114128:3960186-3960446 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References