Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2523690..2524252 Replicon chromosome
Accession NZ_CP114128
Organism Escherichia coli strain PE164

Toxin (Protein)


Gene name higB Uniprot ID L4J948
Locus tag LZG51_RS12225 Protein ID WP_000605676.1
Coordinates 2523974..2524252 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag LZG51_RS12220 Protein ID WP_000781370.1
Coordinates 2523690..2523974 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZG51_RS12205 (2519049) 2519049..2522096 + 3048 WP_012311994.1 formate dehydrogenase-N subunit alpha -
LZG51_RS12210 (2522109) 2522109..2522993 + 885 WP_001240582.1 formate dehydrogenase N subunit beta -
LZG51_RS12215 (2522986) 2522986..2523639 + 654 WP_233708319.1 formate dehydrogenase-N subunit gamma -
LZG51_RS12220 (2523690) 2523690..2523974 - 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
LZG51_RS12225 (2523974) 2523974..2524252 - 279 WP_000605676.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LZG51_RS12230 (2524438) 2524438..2525448 - 1011 WP_000642406.1 alcohol dehydrogenase AdhP -
LZG51_RS12235 (2525582) 2525582..2527279 - 1698 WP_000433464.1 malate dehydrogenase -
LZG51_RS12240 (2527436) 2527436..2527573 - 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
LZG51_RS12245 (2527675) 2527675..2527890 - 216 WP_096220623.1 biofilm-dependent modulation protein -
LZG51_RS12250 (2528235) 2528235..2528666 + 432 WP_000152305.1 peroxiredoxin OsmC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T266276 WP_000605676.1 NZ_CP114128:c2524252-2523974 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT266276 WP_000781370.1 NZ_CP114128:c2523974-2523690 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G6T1

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References