Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1062845..1063572 Replicon chromosome
Accession NZ_CP114128
Organism Escherichia coli strain PE164

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag LZG51_RS05125 Protein ID WP_096220540.1
Coordinates 1062845..1063156 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LZG51_RS05130 Protein ID WP_000126294.1
Coordinates 1063153..1063572 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZG51_RS05095 (1057987) 1057987..1059696 + 1710 WP_001288134.1 formate hydrogenlyase subunit HycE -
LZG51_RS05100 (1059706) 1059706..1060248 + 543 WP_000493785.1 formate hydrogenlyase subunit HycF -
LZG51_RS05105 (1060248) 1060248..1061015 + 768 WP_000067401.1 formate hydrogenlyase subunit HycG -
LZG51_RS05110 (1061012) 1061012..1061422 + 411 WP_001291921.1 formate hydrogenlyase assembly protein HycH -
LZG51_RS05115 (1061415) 1061415..1061885 + 471 WP_000132961.1 hydrogenase maturation peptidase HycI -
LZG51_RS05120 (1061928) 1061928..1062683 + 756 WP_001360181.1 hypothetical protein -
LZG51_RS05125 (1062845) 1062845..1063156 + 312 WP_096220540.1 type II toxin-antitoxin system HigB family toxin Toxin
LZG51_RS05130 (1063153) 1063153..1063572 + 420 WP_000126294.1 helix-turn-helix domain-containing protein Antitoxin
LZG51_RS05135 (1063686) 1063686..1065110 - 1425 WP_000110316.1 6-phospho-beta-glucosidase AscB -
LZG51_RS05140 (1065119) 1065119..1066576 - 1458 WP_001107820.1 PTS cellobiose/arbutin/salicin transporter subunit IIBC -
LZG51_RS05145 (1066836) 1066836..1067846 + 1011 WP_233708313.1 DNA-binding transcriptional regulator AscG -
LZG51_RS05150 (1067995) 1067995..1068522 + 528 WP_153645451.1 electron transport protein HydN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12426.17 Da        Isoelectric Point: 9.7105

>T266271 WP_096220540.1 NZ_CP114128:1062845-1063156 [Escherichia coli]
MHIISKVPFEESARKYPNDALALQALYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.42 Da        Isoelectric Point: 4.4596

>AT266271 WP_000126294.1 NZ_CP114128:1063153-1063572 [Escherichia coli]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References