Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 604974..605773 Replicon chromosome
Accession NZ_CP114128
Organism Escherichia coli strain PE164

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag LZG51_RS02915 Protein ID WP_048969505.1
Coordinates 604974..605438 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag LZG51_RS02920 Protein ID WP_001307405.1
Coordinates 605438..605773 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZG51_RS02885 (599975) 599975..600409 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
LZG51_RS02890 (600427) 600427..601305 - 879 WP_137505491.1 PTS N-acetylgalactosamine transporter subunit IID -
LZG51_RS02895 (601295) 601295..602074 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
LZG51_RS02900 (602085) 602085..602558 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
LZG51_RS02905 (602581) 602581..603861 - 1281 WP_233708274.1 tagatose-bisphosphate aldolase subunit KbaZ -
LZG51_RS02910 (604110) 604110..604919 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
LZG51_RS02915 (604974) 604974..605438 - 465 WP_048969505.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
LZG51_RS02920 (605438) 605438..605773 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
LZG51_RS02925 (605922) 605922..607493 - 1572 WP_001273763.1 galactarate dehydratase -
LZG51_RS02930 (607868) 607868..609202 + 1335 WP_000599633.1 galactarate/glucarate/glycerate transporter GarP -
LZG51_RS02935 (609218) 609218..609988 + 771 WP_024250085.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17862.33 Da        Isoelectric Point: 9.6924

>T266268 WP_048969505.1 NZ_CP114128:c605438-604974 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFIKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT266268 WP_001307405.1 NZ_CP114128:c605773-605438 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References