Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1487426..1488018 Replicon chromosome
Accession NZ_CP114115
Organism Pseudomonas sp. GXZC

Toxin (Protein)


Gene name graT Uniprot ID A0A0A1Z373
Locus tag OZ428_RS06890 Protein ID WP_038846016.1
Coordinates 1487426..1487704 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag OZ428_RS06895 Protein ID WP_133074516.1
Coordinates 1487713..1488018 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OZ428_RS06870 (OZ428_06870) 1483752..1484513 - 762 WP_133074520.1 LuxR C-terminal-related transcriptional regulator -
OZ428_RS06875 (OZ428_06875) 1484607..1485428 + 822 WP_133074519.1 carbon-nitrogen hydrolase family protein -
OZ428_RS06880 (OZ428_06880) 1485562..1486887 + 1326 WP_133074518.1 APC family permease -
OZ428_RS06885 (OZ428_06885) 1486988..1487260 + 273 WP_033896384.1 type B 50S ribosomal protein L31 -
OZ428_RS06890 (OZ428_06890) 1487426..1487704 + 279 WP_038846016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OZ428_RS06895 (OZ428_06895) 1487713..1488018 + 306 WP_133074516.1 HigA family addiction module antitoxin Antitoxin
OZ428_RS06900 (OZ428_06900) 1488202..1489548 + 1347 WP_269132957.1 response regulator -
OZ428_RS06905 (OZ428_06905) 1489597..1490004 + 408 WP_095014884.1 NUDIX domain-containing protein -
OZ428_RS06910 (OZ428_06910) 1490001..1490504 + 504 WP_269132958.1 GNAT family N-acetyltransferase -
OZ428_RS06915 (OZ428_06915) 1490501..1491418 - 918 WP_033896390.1 transcriptional regulator MetR -
OZ428_RS06920 (OZ428_06920) 1491613..1492632 + 1020 WP_061435465.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10520.03 Da        Isoelectric Point: 8.5300

>T266252 WP_038846016.1 NZ_CP114115:1487426-1487704 [Pseudomonas sp. GXZC]
MIRSFKCADTKTLFETGRTRRWSAIVSVIERKLSMLDAAIDLADLRSPPGNRLEALYGDREGQHSIRINGQFRICFIWGP
NGPQNVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11039.88 Da        Isoelectric Point: 7.2775

>AT266252 WP_133074516.1 NZ_CP114115:1487713-1488018 [Pseudomonas sp. GXZC]
MFKNGMRPVHPGEILKEEYLEPLGLTAAALARALHVSAPTVNDIVLMRRSISADVALRLAAALETSAQFWLNLQTAYDLR
TVEIAKGAQISKEVEKVAHCV

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A1Z373

Antitoxin

Source ID Structure

References