26622

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2527525..2528048 Replicon chromosome
Accession NC_017338
Organism Staphylococcus aureus subsp. aureus JKD6159

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag SAA6159_RS12775 Protein ID WP_000074048.1
Coordinates 2527525..2527791 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag SAA6159_RS12780 Protein ID WP_000587616.1
Coordinates 2527791..2528048 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAA6159_RS12755 2522834..2524021 - 1188 WP_000026189.1 MFS transporter -
SAA6159_RS12760 2524415..2525191 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
SAA6159_RS12765 2525184..2525846 - 663 WP_000923521.1 ATP-binding cassette domain-containing protein -
SAA6159_RS12770 2526094..2527170 - 1077 WP_001076671.1 M42 family metallopeptidase -
SAA6159_RS12775 2527525..2527791 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
SAA6159_RS12780 2527791..2528048 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAA6159_RS12790 2528407..2528862 + 456 WP_000732087.1 YehR family lipoprotein -
SAA6159_RS12795 2529030..2530607 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
SAA6159_RS12800 2530802..2531551 + 750 WP_000072467.1 hypothetical protein -
SAA6159_RS12805 2531773..2532966 - 1194 WP_000675410.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T26622 WP_000074048.1 NC_017338:c2527791-2527525 [Staphylococcus aureus subsp. aureus JKD6159]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T26622 NC_017338:c2527791-2527525 [Staphylococcus aureus subsp. aureus JKD6159]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT26622 WP_000587616.1 NC_017338:c2528048-2527791 [Staphylococcus aureus subsp. aureus JKD6159]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT26622 NC_017338:c2528048-2527791 [Staphylococcus aureus subsp. aureus JKD6159]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References