266205

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 4013986..4014581 Replicon chromosome
Accession NZ_CP113974
Organism Pseudomonas aeruginosa strain M6A146

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag OZ175_RS18925 Protein ID WP_003113526.1
Coordinates 4014303..4014581 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OZ175_RS18920 Protein ID WP_003113527.1
Coordinates 4013986..4014291 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OZ175_RS18900 (OZ175_18900) 4009461..4009796 + 336 WP_031633682.1 hypothetical protein -
OZ175_RS18905 (OZ175_18905) 4010328..4012094 - 1767 WP_023087829.1 anti-phage dCTP deaminase -
OZ175_RS18910 (OZ175_18910) 4012351..4013013 - 663 WP_023087830.1 restriction endonuclease -
OZ175_RS18915 (OZ175_18915) 4013237..4013650 - 414 WP_049231965.1 hypothetical protein -
OZ175_RS18920 (OZ175_18920) 4013986..4014291 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
OZ175_RS18925 (OZ175_18925) 4014303..4014581 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OZ175_RS18930 (OZ175_18930) 4014634..4014762 - 129 Protein_3737 integrase -
OZ175_RS18935 (OZ175_18935) 4014910..4017138 + 2229 WP_003113525.1 TonB-dependent receptor -
OZ175_RS18940 (OZ175_18940) 4017208..4017855 - 648 WP_003095021.1 carbonate dehydratase -
OZ175_RS18945 (OZ175_18945) 4017917..4019155 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T266205 WP_003113526.1 NZ_CP113974:c4014581-4014303 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT266205 WP_003113527.1 NZ_CP113974:c4014291-4013986 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References