Detailed information of TA system TA026620

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2496142..2496326
• Replicon: chromosome
• Accession: NC_017338
• Organism: Staphylococcus aureus subsp. aureus JKD6159

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2K4AFL5
• Locus tag: SAA6159_RS12615
• Protein ID: WP_000482651.1
• Coordinates: 2496219..2496326 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2496142..2496202 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAA6159_RS12585	2491686..2492801	-	1116	WP_000971536.1	pyridoxal phosphate-dependent aminotransferase family protein	-
SAA6159_RS12590	2492779..2493786	-	1008	WP_001046645.1	biotin synthase BioB	-
SAA6159_RS12595	2493788..2495146	-	1359	WP_001110075.1	adenosylmethionine--8-amino-7-oxononanoate transaminase	-
SAA6159_RS12600	2495124..2495810	-	687	WP_001217930.1	dethiobiotin synthase	-
SAA6159_RS12605	2495865..2496032	-	168	WP_044026051.1	hypothetical protein	-
-	2496142..2496202	+	61	-	-	Antitoxin
SAA6159_RS12615	2496219..2496326	-	108	WP_000482651.1	type I toxin-antitoxin system Fst family toxin	Toxin
SAA6159_RS12620	2496460..2496846	-	387	WP_000779361.1	flippase GtxA	-
SAA6159_RS12625	2497114..2498256	+	1143	WP_001176854.1	glycerate kinase	-
SAA6159_RS12630	2498316..2498975	+	660	WP_000831296.1	hypothetical protein	-
SAA6159_RS12635	2499158..2500369	+	1212	WP_001191924.1	multidrug effflux MFS transporter	-
SAA6159_RS12640	2500492..2500965	-	474	WP_000456494.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3984.75 Da
• Isoelectric Point: 11.0582

>T26620 WP_000482651.1 NC_017338:c2496326-2496219 [Staphylococcus aureus subsp. aureus JKD6159]
MFNLLINIMTSAISGCLVAFFAHWLRTRSNKKGDK

Nucleotide

• Length: 108 bp

>T26620 NC_017338:c2496326-2496219 [Staphylococcus aureus subsp. aureus JKD6159]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAGCAATAAAAAAGGTGACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT26620 NC_017338:2496142-2496202 [Staphylococcus aureus subsp. aureus JKD6159]
TACATAATAAATTGAACATCTAAATACACCAAGTCCCCTCACTAGTGCAATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2K4AFL5

Antitoxin