Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2475034..2475551 Replicon chromosome
Accession NC_017338
Organism Staphylococcus aureus subsp. aureus JKD6159

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2S6D1N9
Locus tag SAA6159_RS12480 Protein ID WP_000113263.1
Coordinates 2475034..2475300 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag SAA6159_RS12485 Protein ID WP_000584499.1
Coordinates 2475300..2475551 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAA6159_RS12455 2470295..2470831 - 537 WP_000185900.1 GNAT family N-acetyltransferase -
SAA6159_RS12460 2471244..2472068 - 825 WP_000594633.1 formate/nitrite transporter family protein -
SAA6159_RS12465 2472271..2472453 - 183 WP_000079140.1 hypothetical protein -
SAA6159_RS12470 2472540..2473007 - 468 WP_000153340.1 SRPBCC domain-containing protein -
SAA6159_RS12475 2473193..2474740 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
SAA6159_RS12480 2475034..2475300 - 267 WP_000113263.1 Txe/YoeB family addiction module toxin Toxin
SAA6159_RS12485 2475300..2475551 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAA6159_RS12490 2475716..2475816 - 101 Protein_2372 hypothetical protein -
SAA6159_RS12495 2475823..2476422 - 600 WP_000162814.1 DsbA family protein -
SAA6159_RS12500 2476441..2476803 - 363 WP_000819843.1 DUF4467 domain-containing protein -
SAA6159_RS12505 2477058..2478308 + 1251 WP_001012217.1 FemA/FemB family glycyltransferase FmhA -
SAA6159_RS12510 2478405..2479136 - 732 WP_000615462.1 amino acid ABC transporter ATP-binding protein -
SAA6159_RS12515 2479133..2479852 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.01 Da        Isoelectric Point: 10.1628

>T26619 WP_000113263.1 NC_017338:c2475300-2475034 [Staphylococcus aureus subsp. aureus JKD6159]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T26619 NC_017338:c2475300-2475034 [Staphylococcus aureus subsp. aureus JKD6159]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT26619 WP_000584499.1 NC_017338:c2475551-2475300 [Staphylococcus aureus subsp. aureus JKD6159]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT26619 NC_017338:c2475551-2475300 [Staphylococcus aureus subsp. aureus JKD6159]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S6D1N9

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References