Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4009898..4010531 Replicon chromosome
Accession NZ_CP113951
Organism Rhodococcus sp. JS3073

Toxin (Protein)


Gene name graT Uniprot ID I0WTN6
Locus tag OYT95_RS18210 Protein ID WP_007297374.1
Coordinates 4009898..4010179 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OYT95_RS18215 Protein ID WP_007297375.1
Coordinates 4010238..4010531 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OYT95_RS18185 (OYT95_18185) 4006677..4007117 + 441 WP_255309519.1 MerR family transcriptional regulator -
OYT95_RS18190 (OYT95_18190) 4007322..4007819 - 498 WP_268792127.1 hypothetical protein -
OYT95_RS18195 (OYT95_18195) 4007923..4008483 - 561 WP_146777800.1 hypothetical protein -
OYT95_RS18200 (OYT95_18200) 4008757..4009314 - 558 WP_268792128.1 hypothetical protein -
OYT95_RS18205 (OYT95_18205) 4009524..4009655 + 132 WP_009480666.1 hypothetical protein -
OYT95_RS18210 (OYT95_18210) 4009898..4010179 + 282 WP_007297374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OYT95_RS18215 (OYT95_18215) 4010238..4010531 + 294 WP_007297375.1 HigA family addiction module antitoxin Antitoxin
OYT95_RS18220 (OYT95_18220) 4010755..4011357 + 603 WP_268792129.1 recombinase family protein -
OYT95_RS18225 (OYT95_18225) 4011417..4012178 - 762 WP_039951252.1 hypothetical protein -
OYT95_RS18230 (OYT95_18230) 4012336..4012827 - 492 WP_268792130.1 hypothetical protein -
OYT95_RS18235 (OYT95_18235) 4013162..4013458 - 297 WP_005567379.1 hypothetical protein -
OYT95_RS18240 (OYT95_18240) 4013603..4014943 + 1341 WP_268792131.1 glutathione-independent formaldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-81)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10992.48 Da        Isoelectric Point: 8.9336

>T266188 WP_007297374.1 NZ_CP113951:4009898-4010179 [Rhodococcus sp. JS3073]
VIESFADKETERVFHRQFSKKLPQDIQRIARRRLLLIEAATDVNDLRVPPGNRLEKLSGDRVGQYSVRINDQYRICFIWR
ATAAYDVEITDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10745.39 Da        Isoelectric Point: 7.0123

>AT266188 WP_007297375.1 NZ_CP113951:4010238-4010531 [Rhodococcus sp. JS3073]
MTTDLSPIHPGEILREDFLEPFGITQNRLATIIGVPPRRINEIVLGKRSITADTALRLAKAFGNSAQFWLNIQDRYELDL
AADKIGDALAKITRLSA

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I0WTN6

Antitoxin

Source ID Structure

References