Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3258244..3258841 Replicon chromosome
Accession NZ_CP113948
Organism Flavobacterium praedii strain IMCC34515

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag OYT91_RS13775 Protein ID WP_281238426.1
Coordinates 3258560..3258841 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag OYT91_RS13770 Protein ID WP_281238425.1
Coordinates 3258244..3258546 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OYT91_RS13745 3254234..3255586 + 1353 WP_281238420.1 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase -
OYT91_RS13750 3255588..3256358 + 771 WP_281238421.1 glycosyltransferase family 2 protein -
OYT91_RS13755 3256363..3256746 - 384 WP_281238422.1 ORF6N domain-containing protein -
OYT91_RS13760 3256754..3256891 - 138 WP_281238423.1 ORF6N domain-containing protein -
OYT91_RS13765 3256933..3258243 - 1311 WP_281238424.1 phenylacetate--CoA ligase family protein -
OYT91_RS13770 3258244..3258546 - 303 WP_281238425.1 HigA family addiction module antitoxin Antitoxin
OYT91_RS13775 3258560..3258841 - 282 WP_281238426.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OYT91_RS13780 3258956..3260230 + 1275 WP_281238427.1 phosphoribosylamine--glycine ligase -
OYT91_RS13785 3260298..3260531 - 234 WP_269224320.1 uracil phosphoribosyltransferase -
OYT91_RS13790 3260676..3261605 + 930 WP_281238428.1 DUF6427 family protein -
OYT91_RS13795 3261600..3262253 - 654 WP_269224317.1 uracil phosphoribosyltransferase -
OYT91_RS13800 3262343..3262948 + 606 WP_281238429.1 DUF4254 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(25-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-81)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10956.63 Da        Isoelectric Point: 10.0446

>T266187 WP_281238426.1 NZ_CP113948:c3258841-3258560 [Flavobacterium praedii]
MIISFGSKETEKIWNGIVVKKPSIEIQQISRRKLRMLNNSQDLIDLRIPPSNRLEKLSGNLKEFYSILINNQWRIIFNWE
NGNASNVEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11601.19 Da        Isoelectric Point: 4.7473

>AT266187 WP_281238425.1 NZ_CP113948:c3258546-3258244 [Flavobacterium praedii]
MEKLKNIHPGEILLEEFLVPLDITPYRLSKELKIPQTRISEIAKGNRRITADTAIRLSQYFGNSPKFWLGLQDDYDIEEE
QENKGEEIQGIKPFDNQKVA

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References