266136

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-YefM
Location 1727926..1728431 Replicon chromosome
Accession NZ_CP113865
Organism Caldicellulosiruptor morganii strain DSM 8990

Toxin (Protein)


Gene name yoeB Uniprot ID A0A9E9EF83
Locus tag OTK00_RS08600 Protein ID WP_045169881.1
Coordinates 1727926..1728189 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A9E9EJI2
Locus tag OTK00_RS08605 Protein ID WP_045169882.1
Coordinates 1728174..1728431 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OTK00_RS08570 (OTK00_001714) 1724506..1725204 + 699 WP_045169875.1 TVP38/TMEM64 family protein -
OTK00_RS08575 (OTK00_001715) 1725237..1726499 - 1263 WP_045169876.1 serine--tRNA ligase -
OTK00_RS08585 (OTK00_001717) 1726759..1727181 - 423 WP_045169877.1 hypothetical protein -
OTK00_RS08590 (OTK00_001718) 1727399..1727623 - 225 WP_045169879.1 type II toxin-antitoxin system HicA family toxin -
OTK00_RS08595 (OTK00_001719) 1727625..1727876 - 252 WP_268760767.1 type II toxin-antitoxin system HicB family antitoxin -
OTK00_RS08600 (OTK00_001720) 1727926..1728189 - 264 WP_045169881.1 Txe/YoeB family addiction module toxin Toxin
OTK00_RS08605 (OTK00_001721) 1728174..1728431 - 258 WP_045169882.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
OTK00_RS08610 (OTK00_001722) 1728603..1729364 - 762 WP_045169883.1 ABC transporter ATP-binding protein -
OTK00_RS08615 (OTK00_001723) 1729361..1730158 - 798 WP_045169884.1 energy-coupling factor transporter transmembrane component T -
OTK00_RS08620 (OTK00_001724) 1730167..1730490 - 324 WP_082054642.1 hypothetical protein -
OTK00_RS08625 (OTK00_001725) 1730490..1731164 - 675 Protein_1684 energy-coupling factor ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(43-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10563.46 Da        Isoelectric Point: 9.9836

>T266136 WP_045169881.1 NZ_CP113865:c1728189-1727926 [Caldicellulosiruptor morganii]
MGYKLKFSKYALKDAKKLEECGLDKKAKEILRILKENLYQNPPPYEKLKGELSGKFSRRINIQHRIIYEVLEEEKIVKIY
RMWTHYE

Download         Length: 264 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9861.12 Da        Isoelectric Point: 4.0480

>AT266136 WP_045169882.1 NZ_CP113865:c1728431-1728174 [Caldicellulosiruptor morganii]
MKTMPVTKVRQNIYKIIEQVRETSEPIQITSKKGNAILISEEDWNAIQETLYLLSIPNLKESISDADKVPLDEWEDEEDL
GWDIN

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References