Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 2689483..2689817 Replicon chromosome
Accession NZ_CP113832
Organism Enterococcus faecalis strain M61

Toxin (Protein)


Gene name txpA Uniprot ID Q82Z30
Locus tag OZF29_RS13005 Protein ID WP_002387585.1
Coordinates 2689483..2689626 (+) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 2689558..2689817 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
- (2684507) 2684507..2684683 - 177 NuclAT_14 - -
- (2684541) 2684541..2684695 - 155 NuclAT_7 - -
OZF29_RS12995 (2684835) 2684835..2684939 + 105 WP_021164545.1 putative holin-like toxin -
- (2684872) 2684872..2685127 - 256 NuclAT_0 - -
OZF29_RS13000 (2685129) 2685129..2688887 - 3759 WP_116495142.1 WxL domain-containing protein -
- (2689228) 2689228..2689372 - 145 NuclAT_5 - -
- (2689230) 2689230..2689372 - 143 NuclAT_15 - -
OZF29_RS13005 (2689483) 2689483..2689626 + 144 WP_002387585.1 putative holin-like toxin Toxin
- (2689601) 2689601..2689815 - 215 NuclAT_2 - -
- (2689767) 2689767..2689816 + 50 NuclAT_18 - -
- (2689558) 2689558..2689817 - 260 NuclAT_13 - Antitoxin
OZF29_RS13010 (2689817) 2689817..2692861 - 3045 WP_161970605.1 WxL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5244.37 Da        Isoelectric Point: 10.5719

>T266124 WP_002387585.1 NZ_CP113832:2689483-2689626 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILKVVKEDKKK

Download         Length: 144 bp

Antitoxin


Download         Length: 260 bp

>AT266124 NZ_CP113832:c2689817-2689558 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGATGGTCGTTGTGCTATA
ATAGCATTGAAAAGAGAGATATGCTGTAACATACCTCTCTAGTGTAGAGCCGTTTAAGACGGTGACTTTTTGGATTATTT
AAAAATAACCGTACTTGGTCAAAGTAGACGGTTATTTTTTCTTGTCTTCTTTAACAACCTTTAGGATTCCGAAGATTAAA
GTCGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A059MXV6

Antitoxin

Download structure file

References