Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2065202..2065616 Replicon chromosome
Accession NC_017338
Organism Staphylococcus aureus subsp. aureus JKD6159

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag SAA6159_RS10300 Protein ID WP_001065123.1
Coordinates 2065365..2065616 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag SAA6159_RS15320 Protein ID WP_000028424.1
Coordinates 2065202..2065375 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAA6159_RS10255 2061362..2061706 - 345 WP_000402904.1 hypothetical protein -
SAA6159_RS10260 2061837..2062136 - 300 WP_000988330.1 HNH endonuclease -
SAA6159_RS10265 2062368..2062784 - 417 WP_000590122.1 hypothetical protein -
SAA6159_RS10270 2062812..2063012 - 201 WP_000265041.1 DUF1514 family protein -
SAA6159_RS10275 2063012..2063662 - 651 WP_001005262.1 hypothetical protein -
SAA6159_RS10280 2063821..2063970 - 150 WP_000595265.1 transcriptional activator RinB -
SAA6159_RS10285 2063967..2064173 - 207 WP_000195810.1 DUF1381 domain-containing protein -
SAA6159_RS10290 2064210..2064743 - 534 WP_001061836.1 dUTP diphosphatase -
SAA6159_RS15315 2064758..2064919 - 162 WP_000889683.1 hypothetical protein -
SAA6159_RS10295 2064920..2065201 - 282 WP_000454994.1 hypothetical protein -
SAA6159_RS15320 2065202..2065375 - 174 WP_000028424.1 hypothetical protein Antitoxin
SAA6159_RS10300 2065365..2065616 - 252 WP_001065123.1 DUF1024 family protein Toxin
SAA6159_RS10305 2065609..2065974 - 366 WP_001105611.1 hypothetical protein -
SAA6159_RS10310 2065989..2066231 - 243 WP_000131379.1 phi PVL orf 51-like protein -
SAA6159_RS10315 2066235..2066603 - 369 WP_000101275.1 hypothetical protein -
SAA6159_RS10320 2066616..2067020 - 405 WP_000401978.1 RusA family crossover junction endodeoxyribonuclease -
SAA6159_RS10325 2067029..2067247 - 219 WP_000338527.1 hypothetical protein -
SAA6159_RS10330 2067254..2068147 - 894 WP_000148328.1 DnaD domain-containing protein -
SAA6159_RS10335 2068177..2068647 - 471 WP_000934762.1 single-stranded DNA-binding protein -
SAA6159_RS10340 2068648..2069265 - 618 WP_072353921.1 MBL fold metallo-hydrolase -
SAA6159_RS10345 2069346..2070266 - 921 WP_000138475.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - scn / chp / sak / hlb / groEL 2037898..2088923 51025


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9391.25 Da        Isoelectric Point: 3.8464

>T26612 WP_001065123.1 NC_017338:c2065616-2065365 [Staphylococcus aureus subsp. aureus JKD6159]
MNNREQIEQSVISTSAYNGNDTEGLLKEIEDVYKKAQAFDEILDGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T26612 NC_017338:c2065616-2065365 [Staphylococcus aureus subsp. aureus JKD6159]
ATGAATAACCGCGAACAAATCGAACAGTCCGTTATAAGTACTAGTGCGTATAACGGTAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGATGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT26612 WP_000028424.1 NC_017338:c2065375-2065202 [Staphylococcus aureus subsp. aureus JKD6159]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT26612 NC_017338:c2065375-2065202 [Staphylococcus aureus subsp. aureus JKD6159]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCCGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References