Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 2065202..2065616 | Replicon | chromosome |
| Accession | NC_017338 | ||
| Organism | Staphylococcus aureus subsp. aureus JKD6159 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | SAA6159_RS10300 | Protein ID | WP_001065123.1 |
| Coordinates | 2065365..2065616 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | SAA6159_RS15320 | Protein ID | WP_000028424.1 |
| Coordinates | 2065202..2065375 (-) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SAA6159_RS10255 | 2061362..2061706 | - | 345 | WP_000402904.1 | hypothetical protein | - |
| SAA6159_RS10260 | 2061837..2062136 | - | 300 | WP_000988330.1 | HNH endonuclease | - |
| SAA6159_RS10265 | 2062368..2062784 | - | 417 | WP_000590122.1 | hypothetical protein | - |
| SAA6159_RS10270 | 2062812..2063012 | - | 201 | WP_000265041.1 | DUF1514 family protein | - |
| SAA6159_RS10275 | 2063012..2063662 | - | 651 | WP_001005262.1 | hypothetical protein | - |
| SAA6159_RS10280 | 2063821..2063970 | - | 150 | WP_000595265.1 | transcriptional activator RinB | - |
| SAA6159_RS10285 | 2063967..2064173 | - | 207 | WP_000195810.1 | DUF1381 domain-containing protein | - |
| SAA6159_RS10290 | 2064210..2064743 | - | 534 | WP_001061836.1 | dUTP diphosphatase | - |
| SAA6159_RS15315 | 2064758..2064919 | - | 162 | WP_000889683.1 | hypothetical protein | - |
| SAA6159_RS10295 | 2064920..2065201 | - | 282 | WP_000454994.1 | hypothetical protein | - |
| SAA6159_RS15320 | 2065202..2065375 | - | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| SAA6159_RS10300 | 2065365..2065616 | - | 252 | WP_001065123.1 | DUF1024 family protein | Toxin |
| SAA6159_RS10305 | 2065609..2065974 | - | 366 | WP_001105611.1 | hypothetical protein | - |
| SAA6159_RS10310 | 2065989..2066231 | - | 243 | WP_000131379.1 | phi PVL orf 51-like protein | - |
| SAA6159_RS10315 | 2066235..2066603 | - | 369 | WP_000101275.1 | hypothetical protein | - |
| SAA6159_RS10320 | 2066616..2067020 | - | 405 | WP_000401978.1 | RusA family crossover junction endodeoxyribonuclease | - |
| SAA6159_RS10325 | 2067029..2067247 | - | 219 | WP_000338527.1 | hypothetical protein | - |
| SAA6159_RS10330 | 2067254..2068147 | - | 894 | WP_000148328.1 | DnaD domain-containing protein | - |
| SAA6159_RS10335 | 2068177..2068647 | - | 471 | WP_000934762.1 | single-stranded DNA-binding protein | - |
| SAA6159_RS10340 | 2068648..2069265 | - | 618 | WP_072353921.1 | MBL fold metallo-hydrolase | - |
| SAA6159_RS10345 | 2069346..2070266 | - | 921 | WP_000138475.1 | recombinase RecT | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | scn / chp / sak / hlb / groEL | 2037898..2088923 | 51025 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9391.25 Da Isoelectric Point: 3.8464
>T26612 WP_001065123.1 NC_017338:c2065616-2065365 [Staphylococcus aureus subsp. aureus JKD6159]
MNNREQIEQSVISTSAYNGNDTEGLLKEIEDVYKKAQAFDEILDGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEY
MNNREQIEQSVISTSAYNGNDTEGLLKEIEDVYKKAQAFDEILDGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEY
Download Length: 252 bp
>T26612 NC_017338:c2065616-2065365 [Staphylococcus aureus subsp. aureus JKD6159]
ATGAATAACCGCGAACAAATCGAACAGTCCGTTATAAGTACTAGTGCGTATAACGGTAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGATGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGTATTAG
ATGAATAACCGCGAACAAATCGAACAGTCCGTTATAAGTACTAGTGCGTATAACGGTAATGACACAGAGGGATTGCTAAA
AGAGATTGAGGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGATGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGTATTAG
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT26612 WP_000028424.1 NC_017338:c2065375-2065202 [Staphylococcus aureus subsp. aureus JKD6159]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT26612 NC_017338:c2065375-2065202 [Staphylococcus aureus subsp. aureus JKD6159]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCCGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCCGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|